Synthesis and characterization of high-quality skin-cooling sheets containing thermosensitive poly(N-isopropylacrylamid)

Yoshiaki Takegami; Yoshiyuki Yokoyama; Osamu Norisugi; Masahiro Nagatsuma; Koji Takata; Mati Ur Rehman; Kenji Matsunaga; Hideharu Yokoi; Satoshi Fujiki; Teruhiko Makino; Tadamichi Shimizu

doi:10.1002/jbm.b.31839

Synthesis and characterization of high-quality skin-cooling sheets containing thermosensitive poly(N-isopropylacrylamid)

Yoshiaki Takegami, Yoshiyuki Yokoyama, Osamu Norisugi, Masahiro Nagatsuma, Koji Takata, Mati Ur Rehman, Kenji Matsunaga, Hideharu Yokoi, Satoshi Fujiki, Teruhiko Makino, Tadamichi Shimizu^*

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Poly(N-isopropylacrylamide) (PNIPAAm) is the most popular thermosensitive polymer, and exhibits a low critical solution temperature of approximately 32°C. This study aimed to examine the usefulness of new cooling sheets, which are manufactured using a thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) material. We prepared cooling-hydrogel sheets containing PNIPAAm (PNIPAAm sheet). We measured the skin temperature on the arms of the subjects using a thermograph and compared the usefulness of the PNIPAAm sheet and a control cooling-hydrogel sheet that did not contain the PNIPAAm mixture. Thermographic measurements obtained 40 min after the treatment with the cooling sheets showed the skin temperature of the subjects treated with the 3.% (w/w) PNIPAAm sheets to be significantly lower than that of the subjects treated with the control cooling-hydrogel sheet (p < 0.005). Compared with the control sheet, the cooling effect of the new PNIPAAm sheet also persisted for a longer duration (up to 100 min). The PNIPAAm sheets exhibited excellent cooling effects. This sheet may therefore be useful for lowering the body temperature of patients with high-grade fever, such as fever due to influenza infection.

Original language	English
Pages (from-to)	110-113
Number of pages	4
Journal	Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume	98 B
Issue number	1
DOIs	https://doi.org/10.1002/jbm.b.31839
State	Published - 2011/07

Keywords

NIPAAm
cooling
sheet
skin
temperature

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

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10.1002/jbm.b.31839

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Takegami, Y., Yokoyama, Y., Norisugi, O., Nagatsuma, M., Takata, K., Rehman, M. U., Matsunaga, K., Yokoi, H., Fujiki, S., Makino, T., & Shimizu, T. (2011). Synthesis and characterization of high-quality skin-cooling sheets containing thermosensitive poly(N-isopropylacrylamid). Journal of Biomedical Materials Research - Part B Applied Biomaterials, 98 B(1), 110-113. https://doi.org/10.1002/jbm.b.31839

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title = "Synthesis and characterization of high-quality skin-cooling sheets containing thermosensitive poly(N-isopropylacrylamid)",

abstract = "Poly(N-isopropylacrylamide) (PNIPAAm) is the most popular thermosensitive polymer, and exhibits a low critical solution temperature of approximately 32°C. This study aimed to examine the usefulness of new cooling sheets, which are manufactured using a thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) material. We prepared cooling-hydrogel sheets containing PNIPAAm (PNIPAAm sheet). We measured the skin temperature on the arms of the subjects using a thermograph and compared the usefulness of the PNIPAAm sheet and a control cooling-hydrogel sheet that did not contain the PNIPAAm mixture. Thermographic measurements obtained 40 min after the treatment with the cooling sheets showed the skin temperature of the subjects treated with the 3.% (w/w) PNIPAAm sheets to be significantly lower than that of the subjects treated with the control cooling-hydrogel sheet (p < 0.005). Compared with the control sheet, the cooling effect of the new PNIPAAm sheet also persisted for a longer duration (up to 100 min). The PNIPAAm sheets exhibited excellent cooling effects. This sheet may therefore be useful for lowering the body temperature of patients with high-grade fever, such as fever due to influenza infection.",

keywords = "NIPAAm, cooling, sheet, skin, temperature",

author = "Yoshiaki Takegami and Yoshiyuki Yokoyama and Osamu Norisugi and Masahiro Nagatsuma and Koji Takata and Rehman, {Mati Ur} and Kenji Matsunaga and Hideharu Yokoi and Satoshi Fujiki and Teruhiko Makino and Tadamichi Shimizu",

year = "2011",

month = jul,

doi = "10.1002/jbm.b.31839",

language = "英語",

volume = "98 B",

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journal = "Journal of Biomedical Materials Research - Part B Applied Biomaterials",

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Takegami, Y, Yokoyama, Y, Norisugi, O, Nagatsuma, M, Takata, K, Rehman, MU, Matsunaga, K, Yokoi, H, Fujiki, S, Makino, T & Shimizu, T 2011, 'Synthesis and characterization of high-quality skin-cooling sheets containing thermosensitive poly(N-isopropylacrylamid)', Journal of Biomedical Materials Research - Part B Applied Biomaterials, vol. 98 B, no. 1, pp. 110-113. https://doi.org/10.1002/jbm.b.31839

Synthesis and characterization of high-quality skin-cooling sheets containing thermosensitive poly(N-isopropylacrylamid). / Takegami, Yoshiaki; Yokoyama, Yoshiyuki; Norisugi, Osamu et al.
In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 98 B, No. 1, 07.2011, p. 110-113.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis and characterization of high-quality skin-cooling sheets containing thermosensitive poly(N-isopropylacrylamid)

AU - Takegami, Yoshiaki

AU - Yokoyama, Yoshiyuki

AU - Norisugi, Osamu

AU - Nagatsuma, Masahiro

AU - Takata, Koji

AU - Rehman, Mati Ur

AU - Matsunaga, Kenji

AU - Yokoi, Hideharu

AU - Fujiki, Satoshi

AU - Makino, Teruhiko

AU - Shimizu, Tadamichi

PY - 2011/7

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N2 - Poly(N-isopropylacrylamide) (PNIPAAm) is the most popular thermosensitive polymer, and exhibits a low critical solution temperature of approximately 32°C. This study aimed to examine the usefulness of new cooling sheets, which are manufactured using a thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) material. We prepared cooling-hydrogel sheets containing PNIPAAm (PNIPAAm sheet). We measured the skin temperature on the arms of the subjects using a thermograph and compared the usefulness of the PNIPAAm sheet and a control cooling-hydrogel sheet that did not contain the PNIPAAm mixture. Thermographic measurements obtained 40 min after the treatment with the cooling sheets showed the skin temperature of the subjects treated with the 3.% (w/w) PNIPAAm sheets to be significantly lower than that of the subjects treated with the control cooling-hydrogel sheet (p < 0.005). Compared with the control sheet, the cooling effect of the new PNIPAAm sheet also persisted for a longer duration (up to 100 min). The PNIPAAm sheets exhibited excellent cooling effects. This sheet may therefore be useful for lowering the body temperature of patients with high-grade fever, such as fever due to influenza infection.

AB - Poly(N-isopropylacrylamide) (PNIPAAm) is the most popular thermosensitive polymer, and exhibits a low critical solution temperature of approximately 32°C. This study aimed to examine the usefulness of new cooling sheets, which are manufactured using a thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) material. We prepared cooling-hydrogel sheets containing PNIPAAm (PNIPAAm sheet). We measured the skin temperature on the arms of the subjects using a thermograph and compared the usefulness of the PNIPAAm sheet and a control cooling-hydrogel sheet that did not contain the PNIPAAm mixture. Thermographic measurements obtained 40 min after the treatment with the cooling sheets showed the skin temperature of the subjects treated with the 3.% (w/w) PNIPAAm sheets to be significantly lower than that of the subjects treated with the control cooling-hydrogel sheet (p < 0.005). Compared with the control sheet, the cooling effect of the new PNIPAAm sheet also persisted for a longer duration (up to 100 min). The PNIPAAm sheets exhibited excellent cooling effects. This sheet may therefore be useful for lowering the body temperature of patients with high-grade fever, such as fever due to influenza infection.

KW - NIPAAm

KW - cooling

KW - sheet

KW - skin

KW - temperature

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U2 - 10.1002/jbm.b.31839

DO - 10.1002/jbm.b.31839

M3 - 学術論文

C2 - 21563307

AN - SCOPUS:79958072197

SN - 1552-4973

VL - 98 B

SP - 110

EP - 113

JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials

JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials

IS - 1

ER -

Synthesis and characterization of high-quality skin-cooling sheets containing thermosensitive poly(N-isopropylacrylamid)

Abstract

Keywords

ASJC Scopus subject areas

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