Synthesis and biological evaluation of macrosphelide cores

Kentaro Ishihara; Takanori Kawaguchi; Yuji Matsuya; Hiroaki Sakurai; Ikuo Saiki; Hideo Nemoto

doi:10.1002/ejoc.200400338

Synthesis and biological evaluation of macrosphelide cores

Kentaro Ishihara, Takanori Kawaguchi, Yuji Matsuya, Hiroaki Sakurai, Ikuo Saiki, Hideo Nemoto^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The simplified 16-membered core structures of macrosphelides were synthesized in high overall yields starting from methyl (+)- or (-)-3-hydroxybutyrate as the sole chiral source. The antiproliferative activities of these macrosphelide cores against murine colon 26-L5 adenocarcinoma cells were examined, and the results suggest that the oxygen functional groups found in the natural products are essential for their bioactivities.

Original language	English
Pages (from-to)	3973-3978
Number of pages	6
Journal	European Journal of Organic Chemistry
Issue number	19
DOIs	https://doi.org/10.1002/ejoc.200400338
State	Published - 2004/09/27

Keywords

Antitumor agents
Cell adhesion
Cyclization
Macrocycles
Natural products

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

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10.1002/ejoc.200400338

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title = "Synthesis and biological evaluation of macrosphelide cores",

abstract = "The simplified 16-membered core structures of macrosphelides were synthesized in high overall yields starting from methyl (+)- or (-)-3-hydroxybutyrate as the sole chiral source. The antiproliferative activities of these macrosphelide cores against murine colon 26-L5 adenocarcinoma cells were examined, and the results suggest that the oxygen functional groups found in the natural products are essential for their bioactivities.",

keywords = "Antitumor agents, Cell adhesion, Cyclization, Macrocycles, Natural products",

author = "Kentaro Ishihara and Takanori Kawaguchi and Yuji Matsuya and Hiroaki Sakurai and Ikuo Saiki and Hideo Nemoto",

year = "2004",

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doi = "10.1002/ejoc.200400338",

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AU - Ishihara, Kentaro

AU - Kawaguchi, Takanori

AU - Matsuya, Yuji

AU - Sakurai, Hiroaki

AU - Saiki, Ikuo

AU - Nemoto, Hideo

PY - 2004/9/27

Y1 - 2004/9/27

N2 - The simplified 16-membered core structures of macrosphelides were synthesized in high overall yields starting from methyl (+)- or (-)-3-hydroxybutyrate as the sole chiral source. The antiproliferative activities of these macrosphelide cores against murine colon 26-L5 adenocarcinoma cells were examined, and the results suggest that the oxygen functional groups found in the natural products are essential for their bioactivities.

AB - The simplified 16-membered core structures of macrosphelides were synthesized in high overall yields starting from methyl (+)- or (-)-3-hydroxybutyrate as the sole chiral source. The antiproliferative activities of these macrosphelide cores against murine colon 26-L5 adenocarcinoma cells were examined, and the results suggest that the oxygen functional groups found in the natural products are essential for their bioactivities.

KW - Antitumor agents

KW - Cell adhesion

KW - Cyclization

KW - Macrocycles

KW - Natural products

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DO - 10.1002/ejoc.200400338

M3 - 学術論文

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JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 19

ER -

Synthesis and biological evaluation of macrosphelide cores

Abstract

Keywords

ASJC Scopus subject areas

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