TY - JOUR
T1 - Synapse-specific representation of the identity of overlapping memory engrams
AU - Abdou, Kareem
AU - Shehata, Mohammad
AU - Choko, Kiriko
AU - Nishizono, Hirofumi
AU - Matsuo, Mina
AU - Muramatsu, Shin ichi
AU - Inokuchi, Kaoru
N1 - Publisher Copyright:
2017 © The Authors
PY - 2018/6/15
Y1 - 2018/6/15
N2 - Memories are integrated into interconnected networks; nevertheless, each memory has its own identity. How the brain defines specific memory identity out of intermingled memories stored in a shared cell ensemble has remained elusive. We found that after complete retrograde amnesia of auditory fear conditioning in mice, optogenetic stimulation of the auditory inputs to the lateral amygdala failed to induce memory recall, implying that the memory engram no longer existed in that circuit. Complete amnesia of a given fear memory did not affect another linked fear memory encoded in the shared ensemble. Optogenetic potentiation or depotentiation of the plasticity at synapses specific to one memory affected the recall of only that memory. Thus, the sharing of engram cells underlies the linkage between memories, whereas synapse-specific plasticity guarantees the identity and storage of individual memories.
AB - Memories are integrated into interconnected networks; nevertheless, each memory has its own identity. How the brain defines specific memory identity out of intermingled memories stored in a shared cell ensemble has remained elusive. We found that after complete retrograde amnesia of auditory fear conditioning in mice, optogenetic stimulation of the auditory inputs to the lateral amygdala failed to induce memory recall, implying that the memory engram no longer existed in that circuit. Complete amnesia of a given fear memory did not affect another linked fear memory encoded in the shared ensemble. Optogenetic potentiation or depotentiation of the plasticity at synapses specific to one memory affected the recall of only that memory. Thus, the sharing of engram cells underlies the linkage between memories, whereas synapse-specific plasticity guarantees the identity and storage of individual memories.
UR - http://www.scopus.com/inward/record.url?scp=85054440814&partnerID=8YFLogxK
U2 - 10.1126/science.aat3810
DO - 10.1126/science.aat3810
M3 - 学術論文
C2 - 29903972
AN - SCOPUS:85054440814
SN - 0036-8075
VL - 360
SP - 1227
EP - 1231
JO - Science
JF - Science
IS - 6394
ER -