Successful management of refractory constipation using Kampo medicine Mashiningan in a patient with wild-type ATTR cardiac amyloidosis

Teruhiko Imamura; Masakazu Hori; Shuhei Tanaka; Koichiro Kinugawa

doi:10.1016/j.jccase.2021.06.004

Successful management of refractory constipation using Kampo medicine Mashiningan in a patient with wild-type ATTR cardiac amyloidosis

Teruhiko Imamura^*, Masakazu Hori, Shuhei Tanaka, Koichiro Kinugawa

^*Corresponding author for this work

Internal Medicine （2）

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A wild-type ATTR amyloidosis is a systemic disease with multi-organ dysfunction, involving heart, kidney, skin, and gastrointestinal tract, due to deposition of wild-type transthyretin in each organ. We had a 76-year-old man diagnosed with wild-type ATTR cardiac amyloidosis, whose heart failure symptom improved by anti-heart failure medications but constipation refractory to multiple conventional medications persisted. Following the conversion from lubiprostone to Kampo medicine mashiningan, his average days per one evacuation decreased from around 7.0 days down to 1.6 days. Mashininigan might be an alternative option to improve refractory constipation in patients with cardiac amyloidosis. <Learning objective: Mashininigan might be an alternative option to improve refractory constipation in patients with cardiac amyloidosis.>

Original language	English
Pages (from-to)	34-36
Number of pages	3
Journal	Journal of Cardiology Cases
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/j.jccase.2021.06.004
State	Published - 2022/01

Keywords

Heart failure
Hemodynamics
Tafamidis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jccase.2021.06.004

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title = "Successful management of refractory constipation using Kampo medicine Mashiningan in a patient with wild-type ATTR cardiac amyloidosis",

abstract = "A wild-type ATTR amyloidosis is a systemic disease with multi-organ dysfunction, involving heart, kidney, skin, and gastrointestinal tract, due to deposition of wild-type transthyretin in each organ. We had a 76-year-old man diagnosed with wild-type ATTR cardiac amyloidosis, whose heart failure symptom improved by anti-heart failure medications but constipation refractory to multiple conventional medications persisted. Following the conversion from lubiprostone to Kampo medicine mashiningan, his average days per one evacuation decreased from around 7.0 days down to 1.6 days. Mashininigan might be an alternative option to improve refractory constipation in patients with cardiac amyloidosis. ",

keywords = "Heart failure, Hemodynamics, Tafamidis",

author = "Teruhiko Imamura and Masakazu Hori and Shuhei Tanaka and Koichiro Kinugawa",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2022",

month = jan,

doi = "10.1016/j.jccase.2021.06.004",

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T1 - Successful management of refractory constipation using Kampo medicine Mashiningan in a patient with wild-type ATTR cardiac amyloidosis

AU - Imamura, Teruhiko

AU - Hori, Masakazu

AU - Tanaka, Shuhei

AU - Kinugawa, Koichiro

PY - 2022/1

Y1 - 2022/1

N2 - A wild-type ATTR amyloidosis is a systemic disease with multi-organ dysfunction, involving heart, kidney, skin, and gastrointestinal tract, due to deposition of wild-type transthyretin in each organ. We had a 76-year-old man diagnosed with wild-type ATTR cardiac amyloidosis, whose heart failure symptom improved by anti-heart failure medications but constipation refractory to multiple conventional medications persisted. Following the conversion from lubiprostone to Kampo medicine mashiningan, his average days per one evacuation decreased from around 7.0 days down to 1.6 days. Mashininigan might be an alternative option to improve refractory constipation in patients with cardiac amyloidosis.

AB - A wild-type ATTR amyloidosis is a systemic disease with multi-organ dysfunction, involving heart, kidney, skin, and gastrointestinal tract, due to deposition of wild-type transthyretin in each organ. We had a 76-year-old man diagnosed with wild-type ATTR cardiac amyloidosis, whose heart failure symptom improved by anti-heart failure medications but constipation refractory to multiple conventional medications persisted. Following the conversion from lubiprostone to Kampo medicine mashiningan, his average days per one evacuation decreased from around 7.0 days down to 1.6 days. Mashininigan might be an alternative option to improve refractory constipation in patients with cardiac amyloidosis.

KW - Heart failure

KW - Hemodynamics

KW - Tafamidis

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DO - 10.1016/j.jccase.2021.06.004

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AN - SCOPUS:85109096080

SN - 1878-5409

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ER -

Successful management of refractory constipation using Kampo medicine Mashiningan in a patient with wild-type ATTR cardiac amyloidosis

Abstract

Keywords

ASJC Scopus subject areas

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