SOD/catalase mimetic platinum nanoparticles inhibit heat-induced apoptosis in human lymphoma U937 and HH cells

Yoko Yoshihisa, Qing Li Zhao, Mariame Ali Hassan, Zhang Li Wei, Megumi Furuichi, Yusei Miyamoto, Takashi Kondo*, Tadamichi Shimizu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Platinum nanoparticles (Pt-NPs) are known to possess anti-tumouric activity and the ability to scavenge superoxides and peroxides indicating that they can act as superoxide dismutase (SOD)/catalase mimetics. These potentials seem useful in the protection and/or amelioration of oxidative stress-associated pathologies, but, when they are combined with a therapeutic modality that depends upon the mediation of reactive oxygen species in cell killing induction, the effect of Pt-NPs might be questionable. Here, the effects of polyacrylic acid-capped Pt-NPs (nano-Pts) on hyperthermia (HT)-induced apoptosis and the underlying molecular mechanisms were investigated in human myelomonocytic lymphoma U937 and human cutaneous T-cell lymphoma HH cells. The results showed that the pre-treatment with nano-Pts significantly inhibited HT-induced apoptosis in a dose-dependent manner. Superoxide, but not peroxides, was suppressed to varying extents. All pathways involved in apoptosis execution were also negatively affected. The results reveal that the combination of nano-Pts and HT could result in HT-desensitization.

Original languageEnglish
Pages (from-to)326-335
Number of pages10
JournalFree Radical Research
Volume45
Issue number3
DOIs
StatePublished - 2011/03

Keywords

  • Platinum nanoparticles
  • ROS
  • apoptosis
  • lymphoma cells

ASJC Scopus subject areas

  • Biochemistry

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