TY - JOUR
T1 - Shanpanootols g and h, diterpenoids from the rhizomes of kaempferia pulchra collected in myanmar and their vpr inhibitory activities
AU - Win, Nwet Nwet
AU - Kodama, Takeshi
AU - Htoo, Zin Paing
AU - Hnin, Saw Yu Yu
AU - Ngwe, Hla
AU - Abe, Ikuro
AU - Morita, Hiroyuki
N1 - Publisher Copyright:
© 2021 The Pharmaceutical Society of Japan.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Two new trihydroxy derivative of Δ8(14),15-isopimarane diterpenoids, shanpanootols G (1) and H (2), along with three known analogues were isolated from the ethyl acetate-soluble extract of Kaempferia pulchra rhizomes collected in Shan State of Myanmar. The structures of these compounds including their absolute configurations were elucidated by the combination of one dimensional (1D) and 2D-NMR spectroscopic methods, high resolution mass spectrometric technique, and the experimental and the calculated electronic circular dichroism (ECD) data. The isopimarane diterpenoids (1-5) were tested for their Viral protein R (Vpr) inhibitory activities against TREx-HeLa-Vpr cells. Shanpanootol H (2) and (1R,2S,5S,9R,10S,13R)-1,2- dihydroxypimara-8(14),15-dien-7-one (4) exhibited anti-Vpr activities at the 5 μ M treated dose.
AB - Two new trihydroxy derivative of Δ8(14),15-isopimarane diterpenoids, shanpanootols G (1) and H (2), along with three known analogues were isolated from the ethyl acetate-soluble extract of Kaempferia pulchra rhizomes collected in Shan State of Myanmar. The structures of these compounds including their absolute configurations were elucidated by the combination of one dimensional (1D) and 2D-NMR spectroscopic methods, high resolution mass spectrometric technique, and the experimental and the calculated electronic circular dichroism (ECD) data. The isopimarane diterpenoids (1-5) were tested for their Viral protein R (Vpr) inhibitory activities against TREx-HeLa-Vpr cells. Shanpanootol H (2) and (1R,2S,5S,9R,10S,13R)-1,2- dihydroxypimara-8(14),15-dien-7-one (4) exhibited anti-Vpr activities at the 5 μ M treated dose.
KW - Kaempferia pulchra
KW - Shanpanootol G
KW - Shanpanootol H
KW - TREx-HeLa-Vpr cell
KW - Viral protein R (Vpr) inhibitory activity
KW - Δ8(14),15-isopimarane diterpenoid
UR - http://www.scopus.com/inward/record.url?scp=85114102242&partnerID=8YFLogxK
U2 - 10.1248/cpb.c21-00326
DO - 10.1248/cpb.c21-00326
M3 - 総説
C2 - 34470956
AN - SCOPUS:85114102242
SN - 0009-2363
VL - 69
SP - 913
EP - 917
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 9
ER -