Shanpanootols A-F, diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activities

Nwet Nwet Win; Takeshi Kodama; Zin Paing Htoo; Saw Yu Yu Hnin; Hla Ngwe; Ikuro Abe; Hiroyuki Morita

doi:10.1016/j.fitote.2021.104870

Shanpanootols A-F, diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activities

Nwet Nwet Win, Takeshi Kodama, Zin Paing Htoo, Saw Yu Yu Hnin, Hla Ngwe, Ikuro Abe, Hiroyuki Morita^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Six new isopimarane diterpenoids, shanpanootols A-F (1–6), along with two known analogues, were isolated from the ethyl acetate-soluble extract of Kaempferia pulchra rhizomes collected in Myanmar. The structures of these compounds were elucidated by extensive spectroscopic techniques such as 1D and 2D NMR and HRESIMS. The absolute configuration of 1 was determined by the modified Mosher method. The new isolates (1–6) were tested for their Vpr inhibitory activities against TREx-HeLa-Vpr cells. Shanpanootols C (3) and E (5) inhibited Vpr at doses of 2.5 and 5 μM, respectively.

Original language	English
Article number	104870
Journal	Fitoterapia
Volume	151
DOIs	https://doi.org/10.1016/j.fitote.2021.104870
State	Published - 2021/06

Keywords

Isopimarane diterpenoid
Kaempferia pulchra
Myanmar
Shanpanootols
Vpr

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/j.fitote.2021.104870

Cite this

@article{e3239e4b090c44a68cb72623e245938f,

title = "Shanpanootols A-F, diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activities",

abstract = "Six new isopimarane diterpenoids, shanpanootols A-F (1–6), along with two known analogues, were isolated from the ethyl acetate-soluble extract of Kaempferia pulchra rhizomes collected in Myanmar. The structures of these compounds were elucidated by extensive spectroscopic techniques such as 1D and 2D NMR and HRESIMS. The absolute configuration of 1 was determined by the modified Mosher method. The new isolates (1–6) were tested for their Vpr inhibitory activities against TREx-HeLa-Vpr cells. Shanpanootols C (3) and E (5) inhibited Vpr at doses of 2.5 and 5 μM, respectively.",

keywords = "Isopimarane diterpenoid, Kaempferia pulchra, Myanmar, Shanpanootols, Vpr",

author = "Win, {Nwet Nwet} and Takeshi Kodama and Htoo, {Zin Paing} and Hnin, {Saw Yu Yu} and Hla Ngwe and Ikuro Abe and Hiroyuki Morita",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = jun,

doi = "10.1016/j.fitote.2021.104870",

language = "英語",

volume = "151",

journal = "Fitoterapia",

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T1 - Shanpanootols A-F, diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activities

AU - Win, Nwet Nwet

AU - Kodama, Takeshi

AU - Htoo, Zin Paing

AU - Hnin, Saw Yu Yu

AU - Ngwe, Hla

AU - Abe, Ikuro

AU - Morita, Hiroyuki

PY - 2021/6

Y1 - 2021/6

N2 - Six new isopimarane diterpenoids, shanpanootols A-F (1–6), along with two known analogues, were isolated from the ethyl acetate-soluble extract of Kaempferia pulchra rhizomes collected in Myanmar. The structures of these compounds were elucidated by extensive spectroscopic techniques such as 1D and 2D NMR and HRESIMS. The absolute configuration of 1 was determined by the modified Mosher method. The new isolates (1–6) were tested for their Vpr inhibitory activities against TREx-HeLa-Vpr cells. Shanpanootols C (3) and E (5) inhibited Vpr at doses of 2.5 and 5 μM, respectively.

AB - Six new isopimarane diterpenoids, shanpanootols A-F (1–6), along with two known analogues, were isolated from the ethyl acetate-soluble extract of Kaempferia pulchra rhizomes collected in Myanmar. The structures of these compounds were elucidated by extensive spectroscopic techniques such as 1D and 2D NMR and HRESIMS. The absolute configuration of 1 was determined by the modified Mosher method. The new isolates (1–6) were tested for their Vpr inhibitory activities against TREx-HeLa-Vpr cells. Shanpanootols C (3) and E (5) inhibited Vpr at doses of 2.5 and 5 μM, respectively.

KW - Isopimarane diterpenoid

KW - Kaempferia pulchra

KW - Myanmar

KW - Shanpanootols

KW - Vpr

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U2 - 10.1016/j.fitote.2021.104870

DO - 10.1016/j.fitote.2021.104870

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AN - SCOPUS:85102279688

SN - 0367-326X

VL - 151

JO - Fitoterapia

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M1 - 104870

ER -

Shanpanootols A-F, diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activities

Abstract

Keywords

ASJC Scopus subject areas

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