Pyrrolactams from marine sponge stylissa massa collected from myanmar and their anti-vpr activities

Nwet Nwet Win; Takeshi Kodama; Aung Aung Aye; Khine Zar Wynn Lae; Hla Ngwe; Nang Mya Han; Ikuro Abe; Hiroyuki Morita

doi:10.1248/cpb.c21-00227

Pyrrolactams from marine sponge stylissa massa collected from myanmar and their anti-vpr activities

Nwet Nwet Win, Takeshi Kodama, Aung Aung Aye, Khine Zar Wynn Lae, Hla Ngwe, Nang Mya Han, Ikuro Abe, Hiroyuki Morita^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa massa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 μM and its potency was comparable to that of positive control damnacanthal.

Original language	English
Pages (from-to)	702-705
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	69
Issue number	7
DOIs	https://doi.org/10.1248/cpb.c21-00227
State	Published - 2021/07/01

Keywords

Pyrrolactam
Stylissa massa
Stylissaol A
TREx-HeLa-Viral protein R (Vpr)

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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10.1248/cpb.c21-00227

Cite this

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title = "Pyrrolactams from marine sponge stylissa massa collected from myanmar and their anti-vpr activities",

abstract = "A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa massa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 μM and its potency was comparable to that of positive control damnacanthal.",

keywords = "Pyrrolactam, Stylissa massa, Stylissaol A, TREx-HeLa-Viral protein R (Vpr)",

author = "Win, {Nwet Nwet} and Takeshi Kodama and Aye, {Aung Aung} and Lae, {Khine Zar Wynn} and Hla Ngwe and Han, {Nang Mya} and Ikuro Abe and Hiroyuki Morita",

year = "2021",

month = jul,

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doi = "10.1248/cpb.c21-00227",

language = "英語",

volume = "69",

pages = "702--705",

journal = "Chemical and Pharmaceutical Bulletin",

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publisher = "Pharmaceutical Society of Japan",

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AU - Win, Nwet Nwet

AU - Kodama, Takeshi

AU - Aye, Aung Aung

AU - Lae, Khine Zar Wynn

AU - Ngwe, Hla

AU - Han, Nang Mya

AU - Abe, Ikuro

AU - Morita, Hiroyuki

PY - 2021/7/1

Y1 - 2021/7/1

N2 - A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa massa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 μM and its potency was comparable to that of positive control damnacanthal.

AB - A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa massa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 μM and its potency was comparable to that of positive control damnacanthal.

KW - Pyrrolactam

KW - Stylissa massa

KW - Stylissaol A

KW - TREx-HeLa-Viral protein R (Vpr)

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U2 - 10.1248/cpb.c21-00227

DO - 10.1248/cpb.c21-00227

M3 - 学術論文

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AN - SCOPUS:85109113797

SN - 0009-2363

VL - 69

SP - 702

EP - 705

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 7

ER -

Pyrrolactams from marine sponge stylissa massa collected from myanmar and their anti-vpr activities

Abstract

Keywords

ASJC Scopus subject areas

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