Pyogenic liver abscess due to hypervirulent Klebsiella pneumoniae in a 14-year-old boy

Satoshi Sato; Tomohiro Aoyama; Yoji Uejima; Mihoko Furuichi; Eisuke Suganuma; Tadamasa Takano; Mahoko Ikeda; Miyuki Mizoguchi; Shu Okugawa; Kyoji Moriya; Hideki Niimi; Isao Kitajima; Hiroshi Kawashima; Yutaka Kawano

doi:10.1016/j.jiac.2018.07.006

Pyogenic liver abscess due to hypervirulent Klebsiella pneumoniae in a 14-year-old boy

Satoshi Sato^*, Tomohiro Aoyama, Yoji Uejima, Mihoko Furuichi, Eisuke Suganuma, Tadamasa Takano, Mahoko Ikeda, Miyuki Mizoguchi, Shu Okugawa, Kyoji Moriya, Hideki Niimi, Isao Kitajima, Hiroshi Kawashima, Yutaka Kawano

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A 14-year-old otherwise healthy boy presented with right-sided back pain following high fever. Abdominal computed tomography scan showed a large liver abscess. Klebsiella pneumoniae (KP) was rapidly identified from peripheral blood using the melting temperature mapping (Tm) method, which enables identification of pathogenic microorganisms within four hours after patient sample collection. He was diagnosed with pyogenic liver abscess (PLA) caused by KP on the day of admission. The KP was the hypervirulent (hv) clinical variant (string test positive, serotype K1, sequence type 23, rmpA and magA positive). After intravenous antibiotic therapy and drainage of the abscess, his condition resolved. The highlights of this case report are a healthy child with hypervirulent Klebsiella pneumoniae liver abscess in Japan and the new Tm mapping method for rapid and accurate identification of the pathogenic microorganism.

Original language	English
Pages (from-to)	137-140
Number of pages	4
Journal	Journal of Infection and Chemotherapy
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/j.jiac.2018.07.006
State	Published - 2019/02

Keywords

Children
Drainage
Hypervirulent
Klebsiella pneumoniae
Liver abscess
Melting temperature mapping

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiac.2018.07.006

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Sato, S., Aoyama, T., Uejima, Y., Furuichi, M., Suganuma, E., Takano, T., Ikeda, M., Mizoguchi, M., Okugawa, S., Moriya, K., Niimi, H., Kitajima, I., Kawashima, H., & Kawano, Y. (2019). Pyogenic liver abscess due to hypervirulent Klebsiella pneumoniae in a 14-year-old boy. Journal of Infection and Chemotherapy, 25(2), 137-140. https://doi.org/10.1016/j.jiac.2018.07.006

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abstract = "A 14-year-old otherwise healthy boy presented with right-sided back pain following high fever. Abdominal computed tomography scan showed a large liver abscess. Klebsiella pneumoniae (KP) was rapidly identified from peripheral blood using the melting temperature mapping (Tm) method, which enables identification of pathogenic microorganisms within four hours after patient sample collection. He was diagnosed with pyogenic liver abscess (PLA) caused by KP on the day of admission. The KP was the hypervirulent (hv) clinical variant (string test positive, serotype K1, sequence type 23, rmpA and magA positive). After intravenous antibiotic therapy and drainage of the abscess, his condition resolved. The highlights of this case report are a healthy child with hypervirulent Klebsiella pneumoniae liver abscess in Japan and the new Tm mapping method for rapid and accurate identification of the pathogenic microorganism.",

keywords = "Children, Drainage, Hypervirulent, Klebsiella pneumoniae, Liver abscess, Melting temperature mapping",

author = "Satoshi Sato and Tomohiro Aoyama and Yoji Uejima and Mihoko Furuichi and Eisuke Suganuma and Tadamasa Takano and Mahoko Ikeda and Miyuki Mizoguchi and Shu Okugawa and Kyoji Moriya and Hideki Niimi and Isao Kitajima and Hiroshi Kawashima and Yutaka Kawano",

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doi = "10.1016/j.jiac.2018.07.006",

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AU - Sato, Satoshi

AU - Aoyama, Tomohiro

AU - Uejima, Yoji

AU - Furuichi, Mihoko

AU - Suganuma, Eisuke

AU - Takano, Tadamasa

AU - Ikeda, Mahoko

AU - Mizoguchi, Miyuki

AU - Okugawa, Shu

AU - Moriya, Kyoji

AU - Niimi, Hideki

AU - Kitajima, Isao

AU - Kawashima, Hiroshi

AU - Kawano, Yutaka

PY - 2019/2

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N2 - A 14-year-old otherwise healthy boy presented with right-sided back pain following high fever. Abdominal computed tomography scan showed a large liver abscess. Klebsiella pneumoniae (KP) was rapidly identified from peripheral blood using the melting temperature mapping (Tm) method, which enables identification of pathogenic microorganisms within four hours after patient sample collection. He was diagnosed with pyogenic liver abscess (PLA) caused by KP on the day of admission. The KP was the hypervirulent (hv) clinical variant (string test positive, serotype K1, sequence type 23, rmpA and magA positive). After intravenous antibiotic therapy and drainage of the abscess, his condition resolved. The highlights of this case report are a healthy child with hypervirulent Klebsiella pneumoniae liver abscess in Japan and the new Tm mapping method for rapid and accurate identification of the pathogenic microorganism.

AB - A 14-year-old otherwise healthy boy presented with right-sided back pain following high fever. Abdominal computed tomography scan showed a large liver abscess. Klebsiella pneumoniae (KP) was rapidly identified from peripheral blood using the melting temperature mapping (Tm) method, which enables identification of pathogenic microorganisms within four hours after patient sample collection. He was diagnosed with pyogenic liver abscess (PLA) caused by KP on the day of admission. The KP was the hypervirulent (hv) clinical variant (string test positive, serotype K1, sequence type 23, rmpA and magA positive). After intravenous antibiotic therapy and drainage of the abscess, his condition resolved. The highlights of this case report are a healthy child with hypervirulent Klebsiella pneumoniae liver abscess in Japan and the new Tm mapping method for rapid and accurate identification of the pathogenic microorganism.

KW - Children

KW - Drainage

KW - Hypervirulent

KW - Klebsiella pneumoniae

KW - Liver abscess

KW - Melting temperature mapping

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SN - 1341-321X

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IS - 2

ER -

Pyogenic liver abscess due to hypervirulent Klebsiella pneumoniae in a 14-year-old boy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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