Possible treatment of circadian sleep disorders using daily ketotifen administration

Alsawaf Ahmad; Kouhei Takeuchi; Tomoya Ozaki; Katsuya Unno; Shahid Mohammad; Honami Akechi; Eri Morioka; Kazuki Honda; Masayuki Ikeda

doi:10.1007/s41105-015-0021-y

Possible treatment of circadian sleep disorders using daily ketotifen administration

Alsawaf Ahmad, Kouhei Takeuchi, Tomoya Ozaki, Katsuya Unno, Shahid Mohammad, Honami Akechi, Eri Morioka, Kazuki Honda, Masayuki Ikeda^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Classic H1 histamine receptor (H₁R) antagonists are currently used as over-the-counter sleep aids. However, their overdose administrations rather produce wakefulness. Our previous rat model studies suggest that ketotifen, an early-phase, second-generation H1R antagonist may be a more desirable sleep aid. Here, we further examined daily injections of ketotifen (3 mg/kg, intraperitoneally, for 5 days) 3 h before light onset time in rats and analyzed the effect of ketotifen on the successive free-running locomotor activity rhythms under constant dim red light. We found significant phase-advancement by the daily ketotifen injections, suggesting possible treatment of circadian sleep disorders using daily ketotifen administration.

Original language	English
Pages (from-to)	117-120
Number of pages	4
Journal	Sleep and Biological Rhythms
Volume	14
Issue number	1
DOIs	https://doi.org/10.1007/s41105-015-0021-y
State	Published - 2016/01/01

Keywords

Behavioral feedback
Circadian clock
Sleep-induced phase shifts

ASJC Scopus subject areas

Physiology
Neuropsychology and Physiological Psychology
Neurology
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s41105-015-0021-y

Cite this

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title = "Possible treatment of circadian sleep disorders using daily ketotifen administration",

abstract = "Classic H1 histamine receptor (H1R) antagonists are currently used as over-the-counter sleep aids. However, their overdose administrations rather produce wakefulness. Our previous rat model studies suggest that ketotifen, an early-phase, second-generation H1R antagonist may be a more desirable sleep aid. Here, we further examined daily injections of ketotifen (3 mg/kg, intraperitoneally, for 5 days) 3 h before light onset time in rats and analyzed the effect of ketotifen on the successive free-running locomotor activity rhythms under constant dim red light. We found significant phase-advancement by the daily ketotifen injections, suggesting possible treatment of circadian sleep disorders using daily ketotifen administration.",

keywords = "Behavioral feedback, Circadian clock, Sleep-induced phase shifts",

author = "Alsawaf Ahmad and Kouhei Takeuchi and Tomoya Ozaki and Katsuya Unno and Shahid Mohammad and Honami Akechi and Eri Morioka and Kazuki Honda and Masayuki Ikeda",

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doi = "10.1007/s41105-015-0021-y",

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T1 - Possible treatment of circadian sleep disorders using daily ketotifen administration

AU - Ahmad, Alsawaf

AU - Takeuchi, Kouhei

AU - Ozaki, Tomoya

AU - Unno, Katsuya

AU - Mohammad, Shahid

AU - Akechi, Honami

AU - Morioka, Eri

AU - Honda, Kazuki

AU - Ikeda, Masayuki

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Classic H1 histamine receptor (H1R) antagonists are currently used as over-the-counter sleep aids. However, their overdose administrations rather produce wakefulness. Our previous rat model studies suggest that ketotifen, an early-phase, second-generation H1R antagonist may be a more desirable sleep aid. Here, we further examined daily injections of ketotifen (3 mg/kg, intraperitoneally, for 5 days) 3 h before light onset time in rats and analyzed the effect of ketotifen on the successive free-running locomotor activity rhythms under constant dim red light. We found significant phase-advancement by the daily ketotifen injections, suggesting possible treatment of circadian sleep disorders using daily ketotifen administration.

AB - Classic H1 histamine receptor (H1R) antagonists are currently used as over-the-counter sleep aids. However, their overdose administrations rather produce wakefulness. Our previous rat model studies suggest that ketotifen, an early-phase, second-generation H1R antagonist may be a more desirable sleep aid. Here, we further examined daily injections of ketotifen (3 mg/kg, intraperitoneally, for 5 days) 3 h before light onset time in rats and analyzed the effect of ketotifen on the successive free-running locomotor activity rhythms under constant dim red light. We found significant phase-advancement by the daily ketotifen injections, suggesting possible treatment of circadian sleep disorders using daily ketotifen administration.

KW - Behavioral feedback

KW - Circadian clock

KW - Sleep-induced phase shifts

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U2 - 10.1007/s41105-015-0021-y

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JO - Sleep and Biological Rhythms

JF - Sleep and Biological Rhythms

IS - 1

ER -

Possible treatment of circadian sleep disorders using daily ketotifen administration

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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