TY - JOUR
T1 - Pharmacokinetics of linezolid in the mediastinum and pleural space
AU - Tsuji, Yasuhiro
AU - Hashimoto, Wataru
AU - Taniguchi, Shinichiro
AU - Hiraki, Yoichi
AU - Mizoguchi, Akiko
AU - Yukawa, Eiji
AU - To, Hideto
PY - 2013/11
Y1 - 2013/11
N2 - The purpose of this study was to investigate the penetration of linezolid into the mediastinum and pleural space by comparing its concentration in the serum, mediastinum, and pleural space. The linezolid area under the concentration-versus-time curve from zero to 12h (AUC)mediastinum fluid/serum and AUCpleural fluid/serum ratio were 1.32 and 1.64, respectively. The results suggest that the linezolid concentration in the mediastinum varies as in the serum, and that the concentration in the mediastinum is the same as or greater than that in the serum.
AB - The purpose of this study was to investigate the penetration of linezolid into the mediastinum and pleural space by comparing its concentration in the serum, mediastinum, and pleural space. The linezolid area under the concentration-versus-time curve from zero to 12h (AUC)mediastinum fluid/serum and AUCpleural fluid/serum ratio were 1.32 and 1.64, respectively. The results suggest that the linezolid concentration in the mediastinum varies as in the serum, and that the concentration in the mediastinum is the same as or greater than that in the serum.
KW - Cardiovascular surgery
KW - Linezolid
KW - Mediastinitis
KW - Penetration to mediastinum
KW - Pharmacokinetics
UR - http://www.scopus.com/inward/record.url?scp=84885340021&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2013.03.008
DO - 10.1016/j.ijid.2013.03.008
M3 - 学術論文
C2 - 23684451
AN - SCOPUS:84885340021
SN - 1201-9712
VL - 17
SP - e1060-e1061
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
IS - 11
ER -
