New phloroglucinol derivatives from Indonesian Baeckea frutescens

Takuya Ito; Khoirun Nisa; Senda Kartika Rakainsa; Sbehan Lallo; Hiroyuki Morita

doi:10.1016/j.tet.2017.01.016

New phloroglucinol derivatives from Indonesian Baeckea frutescens

Takuya Ito, Khoirun Nisa, Senda Kartika Rakainsa, Sbehan Lallo, Hiroyuki Morita^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Chemical investigation of the leaves of Baeckea frutescens (Myrtacea) led to the isolation and characterization of five new phloroglucinol derivatives, baeckenones G−K (1–5), together with two known compounds, ursolic acid (6) and humulene (7). The chemical structures were determined by extensive 1D- and 2D-NMR, and MS spectroscopic analyses. Baeckenones J (4) and K (5) exhibited antiproliferative activities against human lung A549 and pancreatic PSN-1 cancer cell lines, with IC₅₀values ranging from 11.8 to 19.2 μM.

Original language	English
Pages (from-to)	1177-1181
Number of pages	5
Journal	Tetrahedron
Volume	73
Issue number	8
DOIs	https://doi.org/10.1016/j.tet.2017.01.016
State	Published - 2017

Keywords

Antiproliferative activity
Baeckea frutescens
Indonesia
Myrtaceae
Phloroglucinol derivatives

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tet.2017.01.016

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title = "New phloroglucinol derivatives from Indonesian Baeckea frutescens",

abstract = "Chemical investigation of the leaves of Baeckea frutescens (Myrtacea) led to the isolation and characterization of five new phloroglucinol derivatives, baeckenones G−K (1–5), together with two known compounds, ursolic acid (6) and humulene (7). The chemical structures were determined by extensive 1D- and 2D-NMR, and MS spectroscopic analyses. Baeckenones J (4) and K (5) exhibited antiproliferative activities against human lung A549 and pancreatic PSN-1 cancer cell lines, with IC50values ranging from 11.8 to 19.2 μM.",

keywords = "Antiproliferative activity, Baeckea frutescens, Indonesia, Myrtaceae, Phloroglucinol derivatives",

author = "Takuya Ito and Khoirun Nisa and Rakainsa, {Senda Kartika} and Sbehan Lallo and Hiroyuki Morita",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

doi = "10.1016/j.tet.2017.01.016",

language = "英語",

volume = "73",

pages = "1177--1181",

journal = "Tetrahedron",

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TY - JOUR

T1 - New phloroglucinol derivatives from Indonesian Baeckea frutescens

AU - Ito, Takuya

AU - Nisa, Khoirun

AU - Rakainsa, Senda Kartika

AU - Lallo, Sbehan

AU - Morita, Hiroyuki

PY - 2017

Y1 - 2017

N2 - Chemical investigation of the leaves of Baeckea frutescens (Myrtacea) led to the isolation and characterization of five new phloroglucinol derivatives, baeckenones G−K (1–5), together with two known compounds, ursolic acid (6) and humulene (7). The chemical structures were determined by extensive 1D- and 2D-NMR, and MS spectroscopic analyses. Baeckenones J (4) and K (5) exhibited antiproliferative activities against human lung A549 and pancreatic PSN-1 cancer cell lines, with IC50values ranging from 11.8 to 19.2 μM.

AB - Chemical investigation of the leaves of Baeckea frutescens (Myrtacea) led to the isolation and characterization of five new phloroglucinol derivatives, baeckenones G−K (1–5), together with two known compounds, ursolic acid (6) and humulene (7). The chemical structures were determined by extensive 1D- and 2D-NMR, and MS spectroscopic analyses. Baeckenones J (4) and K (5) exhibited antiproliferative activities against human lung A549 and pancreatic PSN-1 cancer cell lines, with IC50values ranging from 11.8 to 19.2 μM.

KW - Antiproliferative activity

KW - Baeckea frutescens

KW - Indonesia

KW - Myrtaceae

KW - Phloroglucinol derivatives

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U2 - 10.1016/j.tet.2017.01.016

DO - 10.1016/j.tet.2017.01.016

M3 - 学術論文

AN - SCOPUS:85009745513

SN - 0040-4020

VL - 73

SP - 1177

EP - 1181

JO - Tetrahedron

JF - Tetrahedron

IS - 8

ER -

New phloroglucinol derivatives from Indonesian Baeckea frutescens

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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