Abstract
Chemical investigation of the leaves of Baeckea frutescens (Myrtacea) led to the isolation and characterization of five new phloroglucinol derivatives, baeckenones G−K (1–5), together with two known compounds, ursolic acid (6) and humulene (7). The chemical structures were determined by extensive 1D- and 2D-NMR, and MS spectroscopic analyses. Baeckenones J (4) and K (5) exhibited antiproliferative activities against human lung A549 and pancreatic PSN-1 cancer cell lines, with IC50values ranging from 11.8 to 19.2 μM.
Original language | English |
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Pages (from-to) | 1177-1181 |
Number of pages | 5 |
Journal | Tetrahedron |
Volume | 73 |
Issue number | 8 |
DOIs | |
State | Published - 2017 |
Keywords
- Antiproliferative activity
- Baeckea frutescens
- Indonesia
- Myrtaceae
- Phloroglucinol derivatives
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry