New phloroglucinol derivatives from Indonesian Baeckea frutescens

Takuya Ito, Khoirun Nisa, Senda Kartika Rakainsa, Sbehan Lallo, Hiroyuki Morita*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Chemical investigation of the leaves of Baeckea frutescens (Myrtacea) led to the isolation and characterization of five new phloroglucinol derivatives, baeckenones G−K (1–5), together with two known compounds, ursolic acid (6) and humulene (7). The chemical structures were determined by extensive 1D- and 2D-NMR, and MS spectroscopic analyses. Baeckenones J (4) and K (5) exhibited antiproliferative activities against human lung A549 and pancreatic PSN-1 cancer cell lines, with IC50values ranging from 11.8 to 19.2 μM.

Original languageEnglish
Pages (from-to)1177-1181
Number of pages5
JournalTetrahedron
Volume73
Issue number8
DOIs
StatePublished - 2017

Keywords

  • Antiproliferative activity
  • Baeckea frutescens
  • Indonesia
  • Myrtaceae
  • Phloroglucinol derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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