New paradigm in the role of regulatory T cells during pregnancy

Sayaka Tsuda; Akitoshi Nakashima; Tomoko Shima; Shigeru Saito

doi:10.3389/fimmu.2019.00573

New paradigm in the role of regulatory T cells during pregnancy

Sayaka Tsuda, Akitoshi Nakashima, Tomoko Shima, Shigeru Saito^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

147 Scopus citations

Abstract

Semi-allogenic fetuses are not rejected by the maternal immune system because feto-maternal tolerance induced by CD4+CD25+FoxP3+ regulatory T (Treg) cells is established during pregnancy. Paternal antigen-specific Treg cells accumulate during pregnancy, and seminal plasma priming plays an important role in expanding paternal antigen-specific Treg cells in mouse models. Although paternal-antigen specific Treg cells have not been identified in humans, recent studies suggest that antigen-specific Treg cells exist and expand at the feto-maternal interface in humans. Studies have also revealed that reduction of decidual functional Treg cells occurs during miscarriage with normal fetal chromosomal content, whereas insufficient clonal expansion of decidual Treg cells is observed in preeclampsia. In this review, we will discuss the recent advances in the investigation of mechanisms underlying Treg cell-dependent maintenance of feto-maternal tolerance.

Original language	English
Article number	573
Journal	Frontiers in Immunology
Volume	10
Issue number	MAR
DOIs	https://doi.org/10.3389/fimmu.2019.00573
State	Published - 2019

Keywords

Miscarriage
Preeclampsia
Pregnancy
Regulatory T cells
Seminal plasma

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3389/fimmu.2019.00573

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title = "New paradigm in the role of regulatory T cells during pregnancy",

abstract = "Semi-allogenic fetuses are not rejected by the maternal immune system because feto-maternal tolerance induced by CD4+CD25+FoxP3+ regulatory T (Treg) cells is established during pregnancy. Paternal antigen-specific Treg cells accumulate during pregnancy, and seminal plasma priming plays an important role in expanding paternal antigen-specific Treg cells in mouse models. Although paternal-antigen specific Treg cells have not been identified in humans, recent studies suggest that antigen-specific Treg cells exist and expand at the feto-maternal interface in humans. Studies have also revealed that reduction of decidual functional Treg cells occurs during miscarriage with normal fetal chromosomal content, whereas insufficient clonal expansion of decidual Treg cells is observed in preeclampsia. In this review, we will discuss the recent advances in the investigation of mechanisms underlying Treg cell-dependent maintenance of feto-maternal tolerance.",

keywords = "Miscarriage, Preeclampsia, Pregnancy, Regulatory T cells, Seminal plasma",

author = "Sayaka Tsuda and Akitoshi Nakashima and Tomoko Shima and Shigeru Saito",

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year = "2019",

doi = "10.3389/fimmu.2019.00573",

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AU - Nakashima, Akitoshi

AU - Shima, Tomoko

AU - Saito, Shigeru

N1 - Publisher Copyright: © 2019 Tsuda, Nakashima, Shima and Saito. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PY - 2019

Y1 - 2019

N2 - Semi-allogenic fetuses are not rejected by the maternal immune system because feto-maternal tolerance induced by CD4+CD25+FoxP3+ regulatory T (Treg) cells is established during pregnancy. Paternal antigen-specific Treg cells accumulate during pregnancy, and seminal plasma priming plays an important role in expanding paternal antigen-specific Treg cells in mouse models. Although paternal-antigen specific Treg cells have not been identified in humans, recent studies suggest that antigen-specific Treg cells exist and expand at the feto-maternal interface in humans. Studies have also revealed that reduction of decidual functional Treg cells occurs during miscarriage with normal fetal chromosomal content, whereas insufficient clonal expansion of decidual Treg cells is observed in preeclampsia. In this review, we will discuss the recent advances in the investigation of mechanisms underlying Treg cell-dependent maintenance of feto-maternal tolerance.

AB - Semi-allogenic fetuses are not rejected by the maternal immune system because feto-maternal tolerance induced by CD4+CD25+FoxP3+ regulatory T (Treg) cells is established during pregnancy. Paternal antigen-specific Treg cells accumulate during pregnancy, and seminal plasma priming plays an important role in expanding paternal antigen-specific Treg cells in mouse models. Although paternal-antigen specific Treg cells have not been identified in humans, recent studies suggest that antigen-specific Treg cells exist and expand at the feto-maternal interface in humans. Studies have also revealed that reduction of decidual functional Treg cells occurs during miscarriage with normal fetal chromosomal content, whereas insufficient clonal expansion of decidual Treg cells is observed in preeclampsia. In this review, we will discuss the recent advances in the investigation of mechanisms underlying Treg cell-dependent maintenance of feto-maternal tolerance.

KW - Miscarriage

KW - Preeclampsia

KW - Pregnancy

KW - Regulatory T cells

KW - Seminal plasma

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JO - Frontiers in Immunology

JF - Frontiers in Immunology

IS - MAR

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ER -

New paradigm in the role of regulatory T cells during pregnancy

Abstract

Keywords

ASJC Scopus subject areas

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