Molecular Genetics of Lymphoid Tumorigenesis

F. G. Haluska; Y. Tsujimoto; G. Russo; M. Isobe; C. M. Croce

doi:10.1016/S0079-6603(08)60176-2

Molecular Genetics of Lymphoid Tumorigenesis

F. G. Haluska, Y. Tsujimoto, G. Russo, M. Isobe, C. M. Croce

Life Sciences and Bioengineering

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The body of this work illustrates the utility of the combined cytogenetic and molecular approach to lymphoid tumorigenesis. A number of tumor-specific translocations have proven amenable to dissection by molecular techniques. We have a firm grasp of the general principles that underlie lymphoid neoplasia; in particular, the activation of cellular oncogenes by translocation into genes of the immunoglobulin superfamily is a widespread phenomenon. However, numerous lymphopoietic malignancies are only poorly understood. These remain a challenge for the continued application of these methodologies.

Original language	English
Pages (from-to)	269-280
Number of pages	12
Journal	Progress in Nucleic Acid Research and Molecular Biology
Volume	36
Issue number	C
DOIs	https://doi.org/10.1016/S0079-6603(08)60176-2
State	Published - 1989/01/01

ASJC Scopus subject areas

Molecular Biology

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abstract = "The body of this work illustrates the utility of the combined cytogenetic and molecular approach to lymphoid tumorigenesis. A number of tumor-specific translocations have proven amenable to dissection by molecular techniques. We have a firm grasp of the general principles that underlie lymphoid neoplasia; in particular, the activation of cellular oncogenes by translocation into genes of the immunoglobulin superfamily is a widespread phenomenon. However, numerous lymphopoietic malignancies are only poorly understood. These remain a challenge for the continued application of these methodologies.",

author = "Haluska, {F. G.} and Y. Tsujimoto and G. Russo and M. Isobe and Croce, {C. M.}",

note = "Funding Information: This work was supported in part by National Institutes of Health (NlH) Grant CA 39860, Outstanding Investigator Grant (to C.M.C.). F.G.H. is a trainee of the Medical Scientist Trainee Program at the University of Pennsylvania School of Medicine, under NIH Grant T32 GM 07170.",

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AU - Tsujimoto, Y.

AU - Russo, G.

AU - Isobe, M.

AU - Croce, C. M.

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N2 - The body of this work illustrates the utility of the combined cytogenetic and molecular approach to lymphoid tumorigenesis. A number of tumor-specific translocations have proven amenable to dissection by molecular techniques. We have a firm grasp of the general principles that underlie lymphoid neoplasia; in particular, the activation of cellular oncogenes by translocation into genes of the immunoglobulin superfamily is a widespread phenomenon. However, numerous lymphopoietic malignancies are only poorly understood. These remain a challenge for the continued application of these methodologies.

AB - The body of this work illustrates the utility of the combined cytogenetic and molecular approach to lymphoid tumorigenesis. A number of tumor-specific translocations have proven amenable to dissection by molecular techniques. We have a firm grasp of the general principles that underlie lymphoid neoplasia; in particular, the activation of cellular oncogenes by translocation into genes of the immunoglobulin superfamily is a widespread phenomenon. However, numerous lymphopoietic malignancies are only poorly understood. These remain a challenge for the continued application of these methodologies.

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Molecular Genetics of Lymphoid Tumorigenesis

Abstract

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