@article{82140e93a06c499b9e633b6e7f055888,
title = "Molecular analysis of a t(7;14)(g35;g32) chromosome translocation in a T cell leukemia of a patient with ataxia telangiectasia",
abstract = "Molecular analysis of somatic cell hybrids derived from T cells carrying a t(7;14)(g35;g32) chromosomal translocation from a patient with ataxia telangiectasia and T cell leukemia indicates that the breakpoint on chromosome 14 is proximal to the IgH locus and to the D14S1 locus, while the breakpoint on chromosome 7 involves the T cell receptor β chain locus immediately 5′to Jβ1.5 on chromosome 7. The separation of Vβ and Cβ observed in somatic cell hybrids defined the orientation of the T cell receptor β chain locus on chromosome 7 where the Vβ genes are centromeric and the Cβ genes are telomeric. A novel chromosomal alteration, undetected cytogenetically, was revealed as being an inversion with duplication of the distal band of chromosome 14832. The importance of the 14832 region in the leukemogenic process is discussed.",
author = "Giandomenico Russo and Masaharu Isobe and Luigi Pegoraro and Janet Finan and Nowell, {Peter C.} and Croce, {Carlo M.}",
note = "Funding Information: We thank Jean Letofsky for her technrcal assrstance. Special thanks go to Frank Haluska for rnsrghtful comments. We would like to thank Drs Kay Huebner. Lawrence Finger, Massrmo Negrrni, Elaine Loure. Lalrtha Nagarajan, Yoshihrde Tsufrmoto, Stuart Lessrn. Jacob Kagan, Razelle Kurzrock, and Danuta Kozbor for their support durrng thus work; Dr Louise Showe for kindly provrdtng the T and band Ill probe; MS Marrna Hoffman for editing; and Ms. Charlotte Long for preparation of the manuscrrpt Grandomenrco Russo IS a Dottorando in FISIO-patologra Pediatnca (Unrverstta L{\textquoteright}Aquila-Roma) This work was supported by grant CA39860 from the National Institutes of Health The costs of publrcatron of this article were defrayed in part by the payment of page charges This artrcle must therefore be hereby marked “advertfsement” in accordance with 18 USC Section 1734 solely to rndrcate this fact.",
year = "1988",
month = apr,
day = "8",
doi = "10.1016/0092-8674(88)90495-3",
language = "英語",
volume = "53",
pages = "137--144",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "1",
}