Mild deuteration method of terminal alkynes in heavy water using reusable basic resin

Tsuyoshi Yamada; Kwihwan Park; Yasunari Monguchi; Yoshinari Sawama; Hironao Sajiki

doi:10.1039/c5ra18921g

Mild deuteration method of terminal alkynes in heavy water using reusable basic resin

Tsuyoshi Yamada, Kwihwan Park, Yasunari Monguchi, Yoshinari Sawama^*, Hironao Sajiki

^*Corresponding author for this work

Synthetic and Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The mild and efficient deuteration of terminal alkynes (mono-substituted alkynes) proceeded in the presence of a basic anion exchange resin, WA30, which is a polystyrene polymer bearing a tertiary amine residue on the aromatic nuclei, in heavy water (D₂O) at room temperature. WA30 could be easily removed by a simple filtration and repeatedly reused.

Original language	English
Pages (from-to)	92954-92957
Number of pages	4
Journal	RSC Advances
Volume	5
Issue number	113
DOIs	https://doi.org/10.1039/c5ra18921g
State	Published - 2015

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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title = "Mild deuteration method of terminal alkynes in heavy water using reusable basic resin",

abstract = "The mild and efficient deuteration of terminal alkynes (mono-substituted alkynes) proceeded in the presence of a basic anion exchange resin, WA30, which is a polystyrene polymer bearing a tertiary amine residue on the aromatic nuclei, in heavy water (D2O) at room temperature. WA30 could be easily removed by a simple filtration and repeatedly reused.",

author = "Tsuyoshi Yamada and Kwihwan Park and Yasunari Monguchi and Yoshinari Sawama and Hironao Sajiki",

note = "Publisher Copyright: {\textcopyright} 2015 The Royal Society of Chemistry.",

year = "2015",

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AU - Yamada, Tsuyoshi

AU - Park, Kwihwan

AU - Monguchi, Yasunari

AU - Sawama, Yoshinari

AU - Sajiki, Hironao

PY - 2015

Y1 - 2015

N2 - The mild and efficient deuteration of terminal alkynes (mono-substituted alkynes) proceeded in the presence of a basic anion exchange resin, WA30, which is a polystyrene polymer bearing a tertiary amine residue on the aromatic nuclei, in heavy water (D2O) at room temperature. WA30 could be easily removed by a simple filtration and repeatedly reused.

AB - The mild and efficient deuteration of terminal alkynes (mono-substituted alkynes) proceeded in the presence of a basic anion exchange resin, WA30, which is a polystyrene polymer bearing a tertiary amine residue on the aromatic nuclei, in heavy water (D2O) at room temperature. WA30 could be easily removed by a simple filtration and repeatedly reused.

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U2 - 10.1039/c5ra18921g

DO - 10.1039/c5ra18921g

M3 - 学術論文

AN - SCOPUS:84946605498

SN - 2046-2069

VL - 5

SP - 92954

EP - 92957

JO - RSC Advances

JF - RSC Advances

IS - 113

ER -

Mild deuteration method of terminal alkynes in heavy water using reusable basic resin

Abstract

ASJC Scopus subject areas

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