Kaempulchraols I-O: New isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity

Nwet Nwet Win; Takuya Ito; Simayijiang Aimaiti; Takeshi Kodama; Hiroshi Imagawa; Hla Ngwe; Yoshinori Asakawa; Ikuro Abe; Hiroyuki Morita

doi:10.1016/j.tet.2015.05.075

Kaempulchraols I-O: New isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity

Nwet Nwet Win^*, Takuya Ito, Simayijiang Aimaiti, Takeshi Kodama, Hiroshi Imagawa, Hla Ngwe, Yoshinori Asakawa, Ikuro Abe, Hiroyuki Morita

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The isolation of the CHCl₃ soluble extract of Kaempferia pulchra rhizomes afforded seven new isopimarane diterpenoids, kaempulchraols I-O, together with one known analog. The structures of these compounds were elucidated using 1D and 2D NMR and X-ray diffraction analyses. The antiproliferative activity of the isolated compounds was evaluated against a panel of five human cancer cell lines. Kaempulchraol L exhibited weak antiproliferative activity against PANC-1 and PSN-1 cells with IC₅₀ values of 39.9 and 22.6 μM, respectively.

Original language	English
Pages (from-to)	4707-4713
Number of pages	7
Journal	Tetrahedron
Volume	71
Issue number	29
DOIs	https://doi.org/10.1016/j.tet.2015.05.075
State	Published - 2015

Keywords

Antiproliferative activity
Isopimarane diterpenoids
Kaempferia pulchra
Kaempulchraols

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2015.05.075

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title = "Kaempulchraols I-O: New isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity",

abstract = "The isolation of the CHCl3 soluble extract of Kaempferia pulchra rhizomes afforded seven new isopimarane diterpenoids, kaempulchraols I-O, together with one known analog. The structures of these compounds were elucidated using 1D and 2D NMR and X-ray diffraction analyses. The antiproliferative activity of the isolated compounds was evaluated against a panel of five human cancer cell lines. Kaempulchraol L exhibited weak antiproliferative activity against PANC-1 and PSN-1 cells with IC50 values of 39.9 and 22.6 μM, respectively.",

keywords = "Antiproliferative activity, Isopimarane diterpenoids, Kaempferia pulchra, Kaempulchraols",

author = "Win, {Nwet Nwet} and Takuya Ito and Simayijiang Aimaiti and Takeshi Kodama and Hiroshi Imagawa and Hla Ngwe and Yoshinori Asakawa and Ikuro Abe and Hiroyuki Morita",

year = "2015",

doi = "10.1016/j.tet.2015.05.075",

language = "英語",

volume = "71",

pages = "4707--4713",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd.",

number = "29",

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TY - JOUR

T1 - Kaempulchraols I-O

T2 - New isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity

AU - Win, Nwet Nwet

AU - Ito, Takuya

AU - Aimaiti, Simayijiang

AU - Kodama, Takeshi

AU - Imagawa, Hiroshi

AU - Ngwe, Hla

AU - Asakawa, Yoshinori

AU - Abe, Ikuro

AU - Morita, Hiroyuki

PY - 2015

Y1 - 2015

N2 - The isolation of the CHCl3 soluble extract of Kaempferia pulchra rhizomes afforded seven new isopimarane diterpenoids, kaempulchraols I-O, together with one known analog. The structures of these compounds were elucidated using 1D and 2D NMR and X-ray diffraction analyses. The antiproliferative activity of the isolated compounds was evaluated against a panel of five human cancer cell lines. Kaempulchraol L exhibited weak antiproliferative activity against PANC-1 and PSN-1 cells with IC50 values of 39.9 and 22.6 μM, respectively.

AB - The isolation of the CHCl3 soluble extract of Kaempferia pulchra rhizomes afforded seven new isopimarane diterpenoids, kaempulchraols I-O, together with one known analog. The structures of these compounds were elucidated using 1D and 2D NMR and X-ray diffraction analyses. The antiproliferative activity of the isolated compounds was evaluated against a panel of five human cancer cell lines. Kaempulchraol L exhibited weak antiproliferative activity against PANC-1 and PSN-1 cells with IC50 values of 39.9 and 22.6 μM, respectively.

KW - Antiproliferative activity

KW - Isopimarane diterpenoids

KW - Kaempferia pulchra

KW - Kaempulchraols

UR - http://www.scopus.com/inward/record.url?scp=84949117438&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2015.05.075

DO - 10.1016/j.tet.2015.05.075

M3 - 学術論文

AN - SCOPUS:84949117438

SN - 0040-4020

VL - 71

SP - 4707

EP - 4713

JO - Tetrahedron

JF - Tetrahedron

IS - 29

ER -

Kaempulchraols I-O: New isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity

Abstract

Keywords

ASJC Scopus subject areas

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