Kaempulchraols A-H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar

Nwet Nwet Win; Takuya Ito; Simayijiang Aimaiti; Hiroshi Imagawa; Hla Ngwe; Ikuro Abe; Hiroyuki Morita

doi:10.1021/acs.jnatprod.5b00108

Kaempulchraols A-H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar

Nwet Nwet Win, Takuya Ito, Simayijiang Aimaiti, Hiroshi Imagawa, Hla Ngwe, Ikuro Abe, Hiroyuki Morita^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Eight new diterpenoids, kaempulchraols A-H (1-8), along with five known analogues were isolated from the CHCl₃-soluble extract of rhizomes of Kaempferia pulchra of Myanmar. The structures of these compounds were elucidated using extensive spectroscopic techniques including X-ray diffraction analysis. All the isolates were tested for their antiproliferative activity against a panel of five human cancer cell lines (A549, human lung cancer; HeLa, human cervix cancer; PANC-1 and PSN-1, human pancreatic cancer; MDA-MB-231, human breast cancer) and TIG-3, normal human primary fibroblast cells. Kaempulchraol F (6) exhibited weak activity against the human pancreatic PSN-1 cell line with an IC₅₀ value of 12.3 M.

Original language	English
Pages (from-to)	1113-1118
Number of pages	6
Journal	Journal of Natural Products
Volume	78
Issue number	5
DOIs	https://doi.org/10.1021/acs.jnatprod.5b00108
State	Published - 2015/05/22

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Kaempulchraols A-H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar",

abstract = "Eight new diterpenoids, kaempulchraols A-H (1-8), along with five known analogues were isolated from the CHCl3-soluble extract of rhizomes of Kaempferia pulchra of Myanmar. The structures of these compounds were elucidated using extensive spectroscopic techniques including X-ray diffraction analysis. All the isolates were tested for their antiproliferative activity against a panel of five human cancer cell lines (A549, human lung cancer; HeLa, human cervix cancer; PANC-1 and PSN-1, human pancreatic cancer; MDA-MB-231, human breast cancer) and TIG-3, normal human primary fibroblast cells. Kaempulchraol F (6) exhibited weak activity against the human pancreatic PSN-1 cell line with an IC50 value of 12.3 M.",

author = "Win, {Nwet Nwet} and Takuya Ito and Simayijiang Aimaiti and Hiroshi Imagawa and Hla Ngwe and Ikuro Abe and Hiroyuki Morita",

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year = "2015",

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doi = "10.1021/acs.jnatprod.5b00108",

language = "英語",

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AU - Win, Nwet Nwet

AU - Ito, Takuya

AU - Aimaiti, Simayijiang

AU - Imagawa, Hiroshi

AU - Ngwe, Hla

AU - Abe, Ikuro

AU - Morita, Hiroyuki

PY - 2015/5/22

Y1 - 2015/5/22

N2 - Eight new diterpenoids, kaempulchraols A-H (1-8), along with five known analogues were isolated from the CHCl3-soluble extract of rhizomes of Kaempferia pulchra of Myanmar. The structures of these compounds were elucidated using extensive spectroscopic techniques including X-ray diffraction analysis. All the isolates were tested for their antiproliferative activity against a panel of five human cancer cell lines (A549, human lung cancer; HeLa, human cervix cancer; PANC-1 and PSN-1, human pancreatic cancer; MDA-MB-231, human breast cancer) and TIG-3, normal human primary fibroblast cells. Kaempulchraol F (6) exhibited weak activity against the human pancreatic PSN-1 cell line with an IC50 value of 12.3 M.

AB - Eight new diterpenoids, kaempulchraols A-H (1-8), along with five known analogues were isolated from the CHCl3-soluble extract of rhizomes of Kaempferia pulchra of Myanmar. The structures of these compounds were elucidated using extensive spectroscopic techniques including X-ray diffraction analysis. All the isolates were tested for their antiproliferative activity against a panel of five human cancer cell lines (A549, human lung cancer; HeLa, human cervix cancer; PANC-1 and PSN-1, human pancreatic cancer; MDA-MB-231, human breast cancer) and TIG-3, normal human primary fibroblast cells. Kaempulchraol F (6) exhibited weak activity against the human pancreatic PSN-1 cell line with an IC50 value of 12.3 M.

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Kaempulchraols A-H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar

Abstract

ASJC Scopus subject areas

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