Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe

Laurence Jones; Jacqueline Hollinshead; George W.J. Fleet; Amber L. Thompson; David J. Watkin; Zoltan A. Gal; Sarah F. Jenkinson; Atsushi Kato; Robert J. Nash

doi:10.1016/j.phytol.2010.04.003

Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe

Laurence Jones, Jacqueline Hollinshead, George W.J. Fleet, Amber L. Thompson, David J. Watkin, Zoltan A. Gal, Sarah F. Jenkinson, Atsushi Kato, Robert J. Nash

Hospital Pharmacy

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13 Scopus citations

Abstract

The Australian leguminous tree Castanospermum australe contains the anti-viral glucose analogue indolizidine alkaloid castanospermine. As the result of a search for new bioactive carbohydrate-like compounds we now report the isolation of the novel polyhydroxylated pyrrolizidine alkaloid, 1-epialexine, from the leaves and stems of C. australe. 1-Epialexine is a weak inhibitor of β-mannosidase from Cellullomonas fimi.

Original language	English
Pages (from-to)	133-135
Number of pages	3
Journal	Phytochemistry Letters
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/j.phytol.2010.04.003
State	Published - 2010/09/20

Keywords

1-Epialexine
Castanospermum australe
Fabaceae
Isolation
Pyrrolizidine

ASJC Scopus subject areas

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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10.1016/j.phytol.2010.04.003

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title = "Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe",

abstract = "The Australian leguminous tree Castanospermum australe contains the anti-viral glucose analogue indolizidine alkaloid castanospermine. As the result of a search for new bioactive carbohydrate-like compounds we now report the isolation of the novel polyhydroxylated pyrrolizidine alkaloid, 1-epialexine, from the leaves and stems of C. australe. 1-Epialexine is a weak inhibitor of β-mannosidase from Cellullomonas fimi.",

keywords = "1-Epialexine, Castanospermum australe, Fabaceae, Isolation, Pyrrolizidine",

author = "Laurence Jones and Jacqueline Hollinshead and Fleet, {George W.J.} and Thompson, {Amber L.} and Watkin, {David J.} and Gal, {Zoltan A.} and Jenkinson, {Sarah F.} and Atsushi Kato and Nash, {Robert J.}",

year = "2010",

month = sep,

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doi = "10.1016/j.phytol.2010.04.003",

language = "英語",

volume = "3",

pages = "133--135",

journal = "Phytochemistry Letters",

issn = "1874-3900",

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number = "3",

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TY - JOUR

T1 - Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe

AU - Jones, Laurence

AU - Hollinshead, Jacqueline

AU - Fleet, George W.J.

AU - Thompson, Amber L.

AU - Watkin, David J.

AU - Gal, Zoltan A.

AU - Jenkinson, Sarah F.

AU - Kato, Atsushi

AU - Nash, Robert J.

PY - 2010/9/20

Y1 - 2010/9/20

N2 - The Australian leguminous tree Castanospermum australe contains the anti-viral glucose analogue indolizidine alkaloid castanospermine. As the result of a search for new bioactive carbohydrate-like compounds we now report the isolation of the novel polyhydroxylated pyrrolizidine alkaloid, 1-epialexine, from the leaves and stems of C. australe. 1-Epialexine is a weak inhibitor of β-mannosidase from Cellullomonas fimi.

AB - The Australian leguminous tree Castanospermum australe contains the anti-viral glucose analogue indolizidine alkaloid castanospermine. As the result of a search for new bioactive carbohydrate-like compounds we now report the isolation of the novel polyhydroxylated pyrrolizidine alkaloid, 1-epialexine, from the leaves and stems of C. australe. 1-Epialexine is a weak inhibitor of β-mannosidase from Cellullomonas fimi.

KW - 1-Epialexine

KW - Castanospermum australe

KW - Fabaceae

KW - Isolation

KW - Pyrrolizidine

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U2 - 10.1016/j.phytol.2010.04.003

DO - 10.1016/j.phytol.2010.04.003

M3 - 学術論文

AN - SCOPUS:77957885633

SN - 1874-3900

VL - 3

SP - 133

EP - 135

JO - Phytochemistry Letters

JF - Phytochemistry Letters

IS - 3

ER -

Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe

Abstract

Keywords

ASJC Scopus subject areas

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