TY - JOUR
T1 - Inhibitory effects of triterpenes isolated from hoelen on free radical-induced lysis of red blood cells
AU - Sekiya, Nobuyasu
AU - Goto, Hirozo
AU - Shimada, Yutaka
AU - Endo, Yuichi
AU - Sakakibara, Iwao
AU - Terasawa, Katsutoshi
PY - 2003/2
Y1 - 2003/2
N2 - Hoelen, sclederma of Poria cocos Wolf, has long been used as a sedative and diuretic in traditional medicine. Formerly, we demonstrated that Hoelen in vitro protects red blood cells from AAPH-induced hemolysis. In this study, tests were carried out to identify the main ingredient of Hoelen that has the scavenging effect on free-radicals. Triterpene carboxylic acids isolated from the methanol extract of Hoelen, i.e. pachymic acid, polyporenic acid, 3-epidehydrotumulosic acid, 3β-hydroxylanosta-7,9(11), 24-trien-21-oic acid and 3-o-acetyl-16 α -hydroxytrametenolic acid, were found to have inhibitory activities against AAPH-induced lysis of red blood cells.
AB - Hoelen, sclederma of Poria cocos Wolf, has long been used as a sedative and diuretic in traditional medicine. Formerly, we demonstrated that Hoelen in vitro protects red blood cells from AAPH-induced hemolysis. In this study, tests were carried out to identify the main ingredient of Hoelen that has the scavenging effect on free-radicals. Triterpene carboxylic acids isolated from the methanol extract of Hoelen, i.e. pachymic acid, polyporenic acid, 3-epidehydrotumulosic acid, 3β-hydroxylanosta-7,9(11), 24-trien-21-oic acid and 3-o-acetyl-16 α -hydroxytrametenolic acid, were found to have inhibitory activities against AAPH-induced lysis of red blood cells.
KW - AAPH
KW - Anti-oxidative activity
KW - Hoelen
KW - Triterpenes
UR - http://www.scopus.com/inward/record.url?scp=0037325639&partnerID=8YFLogxK
U2 - 10.1002/ptr.1097
DO - 10.1002/ptr.1097
M3 - 学術論文
C2 - 12601680
AN - SCOPUS:0037325639
SN - 0951-418X
VL - 17
SP - 160
EP - 162
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 2
ER -