Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity

A. Kato; H. Yasuko; H. Goto; J. Hollinshead; R. J. Nash; I. Adachi

doi:10.1016/j.phymed.2007.04.008

Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity

A. Kato^*, H. Yasuko, H. Goto, J. Hollinshead, R. J. Nash, I. Adachi

^*Corresponding author for this work

Hospital Pharmacy

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Aldose reductase inhibitors have considerable potential for the treatment of diabetic complications, without increased risk of hypoglycemia. Search for components inhibiting aldose reductase led to the discovery of active compounds contained in Evodia rutaecarpa Bentham (Rutaceae), which is the one of the component of Kampo-herbal medicine. The hot water extract from the E. rutaecarpa was subjected to distribution or gel filtration chromatography to give an active compound, N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one (rhetsinine). It inhibited aldose reductase with IC₅₀ values of 24.1 μM. Furthermore, rhetsinine inhibited sorbitol accumulation by 79.3% at 100 μM. These results suggested that the E. rutaecarpa derived component, rhetsinine, would be potentially useful in the treatment of diabetic complications.

Original language	English
Pages (from-to)	258-261
Number of pages	4
Journal	Phytomedicine
Volume	16
Issue number	2-3
DOIs	https://doi.org/10.1016/j.phymed.2007.04.008
State	Published - 2009/03

Keywords

Aldose reductase
Diabetic complications
Evodia rutaecarpa
Rhetsinine

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phymed.2007.04.008

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title = "Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity",

abstract = "Aldose reductase inhibitors have considerable potential for the treatment of diabetic complications, without increased risk of hypoglycemia. Search for components inhibiting aldose reductase led to the discovery of active compounds contained in Evodia rutaecarpa Bentham (Rutaceae), which is the one of the component of Kampo-herbal medicine. The hot water extract from the E. rutaecarpa was subjected to distribution or gel filtration chromatography to give an active compound, N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one (rhetsinine). It inhibited aldose reductase with IC50 values of 24.1 μM. Furthermore, rhetsinine inhibited sorbitol accumulation by 79.3% at 100 μM. These results suggested that the E. rutaecarpa derived component, rhetsinine, would be potentially useful in the treatment of diabetic complications.",

keywords = "Aldose reductase, Diabetic complications, Evodia rutaecarpa, Rhetsinine",

author = "A. Kato and H. Yasuko and H. Goto and J. Hollinshead and Nash, {R. J.} and I. Adachi",

year = "2009",

month = mar,

doi = "10.1016/j.phymed.2007.04.008",

language = "英語",

volume = "16",

pages = "258--261",

journal = "Phytomedicine",

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T1 - Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity

AU - Kato, A.

AU - Yasuko, H.

AU - Goto, H.

AU - Hollinshead, J.

AU - Nash, R. J.

AU - Adachi, I.

PY - 2009/3

Y1 - 2009/3

N2 - Aldose reductase inhibitors have considerable potential for the treatment of diabetic complications, without increased risk of hypoglycemia. Search for components inhibiting aldose reductase led to the discovery of active compounds contained in Evodia rutaecarpa Bentham (Rutaceae), which is the one of the component of Kampo-herbal medicine. The hot water extract from the E. rutaecarpa was subjected to distribution or gel filtration chromatography to give an active compound, N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one (rhetsinine). It inhibited aldose reductase with IC50 values of 24.1 μM. Furthermore, rhetsinine inhibited sorbitol accumulation by 79.3% at 100 μM. These results suggested that the E. rutaecarpa derived component, rhetsinine, would be potentially useful in the treatment of diabetic complications.

AB - Aldose reductase inhibitors have considerable potential for the treatment of diabetic complications, without increased risk of hypoglycemia. Search for components inhibiting aldose reductase led to the discovery of active compounds contained in Evodia rutaecarpa Bentham (Rutaceae), which is the one of the component of Kampo-herbal medicine. The hot water extract from the E. rutaecarpa was subjected to distribution or gel filtration chromatography to give an active compound, N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one (rhetsinine). It inhibited aldose reductase with IC50 values of 24.1 μM. Furthermore, rhetsinine inhibited sorbitol accumulation by 79.3% at 100 μM. These results suggested that the E. rutaecarpa derived component, rhetsinine, would be potentially useful in the treatment of diabetic complications.

KW - Aldose reductase

KW - Diabetic complications

KW - Evodia rutaecarpa

KW - Rhetsinine

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U2 - 10.1016/j.phymed.2007.04.008

DO - 10.1016/j.phymed.2007.04.008

M3 - 学術論文

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AN - SCOPUS:59849085141

SN - 0944-7113

VL - 16

SP - 258

EP - 261

JO - Phytomedicine

JF - Phytomedicine

IS - 2-3

ER -

Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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