In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease

Atsushi Kato*, Izumi Nakagome, Shinpei Nakagawa, Kyoko Kinami, Isao Adachi, Sarah F. Jenkinson, Jérôme Désiré, Yves Blériot, Robert J. Nash, George W.J. Fleet, Shuichi Hirono

*Corresponding author for this work

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Keyphrases

Biochemistry, Genetics and Molecular Biology

Pharmacology, Toxicology and Pharmaceutical Science

Chemistry