Abstract
Insulin receptor complementary DNA has been cloned from an insulin-resistant individual whose receptors have impaired tyrosine protein kinase activity. One of this individual's alleles has a mutation in which valine is substituted for Gly996, the third glycine in the conserved Gly-X-Gly-X-X-Gly motif in the putative binding site for adenosine triphosphate. Expression of the mutant receptor by transfection into Chinese hamster ovary cells confirmed that the mutation impairs tyrosine kinase activity.
Original language | English |
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Pages (from-to) | 66-68 |
Number of pages | 3 |
Journal | Science |
Volume | 245 |
Issue number | 4913 |
DOIs | |
State | Published - 1989 |
ASJC Scopus subject areas
- General