Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor

Masato Odawara, Takashi Kadowaki, Ritsuko Yamamoto, Yoshikazu Shibasaki, Kazuyuki Tobe, Domenico Accili, Charles Bevins, Yuhei Mikami, Nobuo Matsuura, Yasuo Akanuma, Fumimaro Takaku, Simeon I. Taylor, Masato Kasuga*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

204 Scopus citations

Abstract

Insulin receptor complementary DNA has been cloned from an insulin-resistant individual whose receptors have impaired tyrosine protein kinase activity. One of this individual's alleles has a mutation in which valine is substituted for Gly996, the third glycine in the conserved Gly-X-Gly-X-X-Gly motif in the putative binding site for adenosine triphosphate. Expression of the mutant receptor by transfection into Chinese hamster ovary cells confirmed that the mutation impairs tyrosine kinase activity.

Original languageEnglish
Pages (from-to)66-68
Number of pages3
JournalScience
Volume245
Issue number4913
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor'. Together they form a unique fingerprint.

Cite this