Future directions of studies for recurrent miscarriage associated with immune etiologies

Shigeru Saito; Akitoshi Nakashima; Tomoko Shima

doi:10.1016/j.jri.2011.03.003

Future directions of studies for recurrent miscarriage associated with immune etiologies

Shigeru Saito^*, Akitoshi Nakashima, Tomoko Shima

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A significant proportion of recurrent pregnancy loss (RPL) is associated with immune etiologies. The immunological environment is different between decidua basalis and decidua parietalis, and also different between RPL cases with normal fetal chromosomes and those with abnormal fetal chromosomes. Recent data show that the immune system in a late-stage abortion is completely different from that in an early-stage abortion. If immunocompetent cells can cause RPL, the immunological environment may be a causative factor, especially in an early-stage abortion, and/or at decidua basalis and/or in the cases of RPL with a normal embryo. Careful examination of the immune system at the decidua basalis in an early-stage abortion in RPL cases with normal fetal chromosome may reveal useful information.

Original language	English
Pages (from-to)	91-95
Number of pages	5
Journal	Journal of Reproductive Immunology
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/j.jri.2011.03.003
State	Published - 2011/06

Keywords

Clinical stage
Decidua basalis
Fetal chromosome
Immune etiology
Recurrent abortion

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynecology

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title = "Future directions of studies for recurrent miscarriage associated with immune etiologies",

abstract = "A significant proportion of recurrent pregnancy loss (RPL) is associated with immune etiologies. The immunological environment is different between decidua basalis and decidua parietalis, and also different between RPL cases with normal fetal chromosomes and those with abnormal fetal chromosomes. Recent data show that the immune system in a late-stage abortion is completely different from that in an early-stage abortion. If immunocompetent cells can cause RPL, the immunological environment may be a causative factor, especially in an early-stage abortion, and/or at decidua basalis and/or in the cases of RPL with a normal embryo. Careful examination of the immune system at the decidua basalis in an early-stage abortion in RPL cases with normal fetal chromosome may reveal useful information.",

keywords = "Clinical stage, Decidua basalis, Fetal chromosome, Immune etiology, Recurrent abortion",

author = "Shigeru Saito and Akitoshi Nakashima and Tomoko Shima",

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doi = "10.1016/j.jri.2011.03.003",

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AU - Saito, Shigeru

AU - Nakashima, Akitoshi

AU - Shima, Tomoko

PY - 2011/6

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N2 - A significant proportion of recurrent pregnancy loss (RPL) is associated with immune etiologies. The immunological environment is different between decidua basalis and decidua parietalis, and also different between RPL cases with normal fetal chromosomes and those with abnormal fetal chromosomes. Recent data show that the immune system in a late-stage abortion is completely different from that in an early-stage abortion. If immunocompetent cells can cause RPL, the immunological environment may be a causative factor, especially in an early-stage abortion, and/or at decidua basalis and/or in the cases of RPL with a normal embryo. Careful examination of the immune system at the decidua basalis in an early-stage abortion in RPL cases with normal fetal chromosome may reveal useful information.

AB - A significant proportion of recurrent pregnancy loss (RPL) is associated with immune etiologies. The immunological environment is different between decidua basalis and decidua parietalis, and also different between RPL cases with normal fetal chromosomes and those with abnormal fetal chromosomes. Recent data show that the immune system in a late-stage abortion is completely different from that in an early-stage abortion. If immunocompetent cells can cause RPL, the immunological environment may be a causative factor, especially in an early-stage abortion, and/or at decidua basalis and/or in the cases of RPL with a normal embryo. Careful examination of the immune system at the decidua basalis in an early-stage abortion in RPL cases with normal fetal chromosome may reveal useful information.

KW - Clinical stage

KW - Decidua basalis

KW - Fetal chromosome

KW - Immune etiology

KW - Recurrent abortion

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DO - 10.1016/j.jri.2011.03.003

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AN - SCOPUS:79959924541

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Future directions of studies for recurrent miscarriage associated with immune etiologies

Abstract

Keywords

ASJC Scopus subject areas

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