Fluoride catalyzed Michael reaction of α-isocyanoesters with α,β-unsaturated carbonyl compounds

Masahiro Murakami*, Naoki Hasegawa, Ikuyoshi Tomita, Masahiko Inouye, Yoshihiko Ito

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The Michael reaction of α-isocyanoesters with α,β-unsaturated carbonyl compounds was efficiently promoted by a catalytic amount of tetrabutylammonium fluoride to produce α-isocyano-δ-ketoesters or silyl ethers of their enols in high yields.

Original languageEnglish
Pages (from-to)1257-1260
Number of pages4
JournalTetrahedron Letters
Volume30
Issue number10
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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