Flavanols and Flavanes from Crinum asiaticum and Their Effects on LPS Signaling Pathway Through the Inhibition of NF- κ B Activation

Kiep Minh Do, Min Kyoung Shin, Takeshi Kodama, Nwet Nwet Win, Prema Prema, Hien Minh Nguyen, Yoshihiro Hayakawa*, Hiroyuki Morita

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Three new flavanols, (2 R,3 S)-7-methoxy-flavan-3-ol (1), (2 R,3 S)-7-hydroxy-flavan-3-ol (2), and (2 R,3 S)-2′-hydroxy-7-methoxy-flavan-3-ol (3), together with two known flavans (4 and 5), were isolated from the chloroform extract of Crinum asiaticum. Their structures were elucidated by various spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and CD data. The isolated compounds 1 and 3 - 5 showed inhibitory activity toward LPS-induced nitric oxide (NO) production. Further investigation of the NF- κ B pathway mechanisms indicated that 1 and 3 - 5 inhibited the LPS-induced IL-6 production and p65 subunit phosphorylation of NF- κ B in RAW264.7 cells, with an effective dose of 10 μM.

Original languageEnglish
Pages (from-to)913-920
Number of pages8
JournalPlanta Medica
Volume88
Issue number11
DOIs
StatePublished - 2022/09/02

Keywords

  • Crinum asiaticum
  • NF- κ B pathway
  • NO inhibition
  • flavanols
  • flavans

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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