First total synthesis of (+)-broussonetine W: Glycosidase inhibition of natural product & analogs

Keyphrases

• Glycosidase Inhibition 100%
• Broussonetines 100%
• First Total Synthesis 100%
• Natural Product Analogues 100%
• IC50 40%
• Potent Inhibitor 40%
• Functional Groups 40%
• Selective Inhibitor 40%
• Polyhydroxylated piperidines 40%
• Unsaturated Ketones 40%
• Regioselectivity 20%
• β-Galactosidase (β-Gal) 20%
• Glucosidase 20%
• Side Chain 20%
• Iminosugars 20%
• Arabinose 20%
• Structure-activity Relationship 20%
• Group by 20%
• Overall Yield 20%
• Natural Products 20%
• Pyrrolidine 20%
• Cyclic Nitrones 20%
• Pyrrolidine Ring 20%
• Synthetic Routes 20%
• Broussonetia Kazinoki 20%
• Core Configuration 20%
• Moraceae 20%
• Inhibition Studies 20%
• Cyclohexanone 20%
• Side Chain Length 20%
• α-bromoketones 20%
• Traditional Chinese Medical 20%
• Treatment Plant 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Glycosidase 100%
• Natural Product 100%
• Pyrrolidine Derivative 60%
• IC50 40%
• Functional Groups 40%
• Galactosidase 20%
• Glucosidase 20%
• Elimination 20%
• Structure Activity Relationship 20%
• Iminosugar 20%
• Nitrone 20%
• Arabinose 20%
• Broussonetia kazinoki 20%
• Cyclohexanone Derivative 20%
• Moraceae 20%
• Medicinal Plant 20%