Expression of hornerin in skin lesions of atopic dermatitis and skin diseases

Teruhiko Makino*, Megumi Mizawa, Keita Takemoto, Tadamichi Shimizu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We have previously identified the filaggrin (FLG)-like protein, hornerin (HRNR). Recently, there have been several reports regarding the relationship between HRNR and atopic dermatitis (AD). In the present study, we examined HRNR expression in the skin lesions of seven unrelated patients with AD to clarify the role of HRNR in the pathogenesis of AD. HRNR was detected in chronic AD lesions (n=4), whereas no HRNR signals were observed in acute AD lesions (n=3). HRNR was detected in the cytokeratin 6-expressing epidermis, and Ki67-positive keratinocytes were more abundant in the HRNR-positive epidermis. These findings suggest that HRNR may be associated with epidermal hyperproliferation in AD lesions. Next, we examined HRNR expression in skin diseases associated with hyperkeratosis. HRNR signals were irregularly observed in different cells from those expressing FLG in epidermolytic ichthyosis and actinic keratosis. Therefore, HRNR may play a unique role in the molecular process of cornification.

Original languageEnglish
Pages (from-to)255-258
Number of pages4
JournalClinical and Experimental Dermatology
Volume49
Issue number3
DOIs
StatePublished - 2024/03

ASJC Scopus subject areas

  • Dermatology

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