Abstract
Background: Bcl-2-associated athanogene 3 (BAG3), a co-chaperone of heat shock protein 70 (HSP70), has been shown to play a role in anti-apoptosis of various malignant tumors. In this study, the expression of BAG3 was examined in human sebaceous gland carcinoma of the eyelid. Materials and Methods: The expression of BAG3 was evaluated by immunohistochemistry of surgical samples from 5. patients with sebaceous gland carcinoma in the eyelid. Results: BAG3 was positive diffusely in the cytoplasm in all patients. The average positive rate of BAG3 was 73.0±26.0% in tumor cells of all patients. Conclusion: BAG3 was highly expressed in sebaceous gland carcinoma of the eyelid. BAG3 may play an important role in the pathogenesis and progression of sebaceous gland carcinoma of the eyelid.
| Original language | English |
|---|---|
| Pages (from-to) | 1931-1934 |
| Number of pages | 4 |
| Journal | Anticancer Research |
| Volume | 37 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2017/04 |
Keywords
- BAG3
- Immunohistochemistry
- Sebaceous gland carcinoma
ASJC Scopus subject areas
- Oncology
- Cancer Research
