Enzymatic synthesis of plant polyketides

Shepo Shi; Hiroyuki Morita; Kiyofumi Wanibuchi; Yuusuke Mizuuchi; Hiroshi Noguchi; Ikuro Abe

doi:10.2174/157017908785133410

Enzymatic synthesis of plant polyketides

Shepo Shi, Hiroyuki Morita, Kiyofumi Wanibuchi, Yuusuke Mizuuchi, Hiroshi Noguchi, Ikuro Abe^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

The functional diversity and catalytic potential of type III polyketide synthases are remarkable. The enzymes catalyze iterative decarboxylative condensations of malonyl unit (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce structurally diverse, pharmaceutically important secondary metabolites. Recent studies have revealed intimate structural details of the enzyme reactions, which enabled the precursor-directed and structure-based engineered biosynthesis of unnatural polyketides.

Original language	English
Pages (from-to)	250-266
Number of pages	17
Journal	Current Organic Synthesis
Volume	5
Issue number	3
DOIs	https://doi.org/10.2174/157017908785133410
State	Published - 2008/08

Keywords

Combinatorial biosynthesis
Enzymatic synthesis
Precursor-directed biosynthesis
Structure-based engineered biosynthesis
Type III polyketide synthase

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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abstract = "The functional diversity and catalytic potential of type III polyketide synthases are remarkable. The enzymes catalyze iterative decarboxylative condensations of malonyl unit (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce structurally diverse, pharmaceutically important secondary metabolites. Recent studies have revealed intimate structural details of the enzyme reactions, which enabled the precursor-directed and structure-based engineered biosynthesis of unnatural polyketides.",

keywords = "Combinatorial biosynthesis, Enzymatic synthesis, Precursor-directed biosynthesis, Structure-based engineered biosynthesis, Type III polyketide synthase",

author = "Shepo Shi and Hiroyuki Morita and Kiyofumi Wanibuchi and Yuusuke Mizuuchi and Hiroshi Noguchi and Ikuro Abe",

year = "2008",

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T1 - Enzymatic synthesis of plant polyketides

AU - Shi, Shepo

AU - Morita, Hiroyuki

AU - Wanibuchi, Kiyofumi

AU - Mizuuchi, Yuusuke

AU - Noguchi, Hiroshi

AU - Abe, Ikuro

PY - 2008/8

Y1 - 2008/8

N2 - The functional diversity and catalytic potential of type III polyketide synthases are remarkable. The enzymes catalyze iterative decarboxylative condensations of malonyl unit (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce structurally diverse, pharmaceutically important secondary metabolites. Recent studies have revealed intimate structural details of the enzyme reactions, which enabled the precursor-directed and structure-based engineered biosynthesis of unnatural polyketides.

AB - The functional diversity and catalytic potential of type III polyketide synthases are remarkable. The enzymes catalyze iterative decarboxylative condensations of malonyl unit (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce structurally diverse, pharmaceutically important secondary metabolites. Recent studies have revealed intimate structural details of the enzyme reactions, which enabled the precursor-directed and structure-based engineered biosynthesis of unnatural polyketides.

KW - Combinatorial biosynthesis

KW - Enzymatic synthesis

KW - Precursor-directed biosynthesis

KW - Structure-based engineered biosynthesis

KW - Type III polyketide synthase

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VL - 5

SP - 250

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JO - Current Organic Synthesis

JF - Current Organic Synthesis

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ER -

Enzymatic synthesis of plant polyketides

Abstract

Keywords

ASJC Scopus subject areas

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