TY - JOUR
T1 - Diagnostic performance between contrast enhancement, proton MR spectroscopy, and amide proton transfer imaging in patients with brain tumors
AU - Sakata, Akihiko
AU - Fushimi, Yasutaka
AU - Okada, Tomohisa
AU - Arakawa, Yoshiki
AU - Kunieda, Takeharu
AU - Minamiguchi, Sachiko
AU - Kido, Aki
AU - Sakashita, Naotaka
AU - Miyamoto, Susumu
AU - Togashi, Kaori
N1 - Publisher Copyright:
© 2017 International Society for Magnetic Resonance in Medicine
PY - 2017/9
Y1 - 2017/9
N2 - Purpose: To explore the relationship among parameters of magnetic resonance spectroscopy (MRS) and amide proton transfer (APT) imaging, and to assess the diagnostic performance of MRS and APT imaging for grading brain tumors in comparison with contrast enhancement of conventional MRI for preoperative grading in patients with brain tumor. Materials and Methods: Institutional Review Board approval and written informed consent were obtained. Forty-one patients with suspected brain tumors were enrolled in the study. Single-voxel MRS and 2D APT imaging of the same slice level were conducted using a 3T MRI scanner. Positive or negative contrast enhancement on T1-weighted images was assessed by two neuroradiologists. Correlations among metabolite concentrations, metabolite ratios, and calculated histogram parameters, including mean APT (APTmean) and the 90th percentile of APT (APT90) were assessed using Spearman's correlation coefficient. Diagnostic performance was evaluated with receiver operating characteristic (ROC) curve analysis for contrast enhancement and MRS and APT imaging. Values of P < 0.05 were considered statistically significant. Results: Positive correlations with statistical significance were found between total concentration of choline (Cho) and APT90 (r = 0.49), and between Cho/creatine (Cr) and APTmean (r = 0.65) as well as APT90 (r = 0.49). A negative correlation with statistical significance was observed between NAA/Cr and APTmean (r = −0.52). According to ROC curves, Cho/Cr, APTmean, APT90, demonstrated higher area under the curve (AUC) values than that of contrast enhancement in grading gliomas. Conclusion: Significant correlations were observed between metabolite concentrations and ratios on MRS and APT values. MRS and APT imaging showed comparable diagnostic capability for grading brain tumors, suggesting that both MRS and APT imaging offer potential for quantitatively assessing similar biological characteristics in brain tumors on noncontrast MRI. Level of Evidence: 2. Technical Efficacy: Stage 2. J. MAGN. RESON. IMAGING 2017;46:732–739.
AB - Purpose: To explore the relationship among parameters of magnetic resonance spectroscopy (MRS) and amide proton transfer (APT) imaging, and to assess the diagnostic performance of MRS and APT imaging for grading brain tumors in comparison with contrast enhancement of conventional MRI for preoperative grading in patients with brain tumor. Materials and Methods: Institutional Review Board approval and written informed consent were obtained. Forty-one patients with suspected brain tumors were enrolled in the study. Single-voxel MRS and 2D APT imaging of the same slice level were conducted using a 3T MRI scanner. Positive or negative contrast enhancement on T1-weighted images was assessed by two neuroradiologists. Correlations among metabolite concentrations, metabolite ratios, and calculated histogram parameters, including mean APT (APTmean) and the 90th percentile of APT (APT90) were assessed using Spearman's correlation coefficient. Diagnostic performance was evaluated with receiver operating characteristic (ROC) curve analysis for contrast enhancement and MRS and APT imaging. Values of P < 0.05 were considered statistically significant. Results: Positive correlations with statistical significance were found between total concentration of choline (Cho) and APT90 (r = 0.49), and between Cho/creatine (Cr) and APTmean (r = 0.65) as well as APT90 (r = 0.49). A negative correlation with statistical significance was observed between NAA/Cr and APTmean (r = −0.52). According to ROC curves, Cho/Cr, APTmean, APT90, demonstrated higher area under the curve (AUC) values than that of contrast enhancement in grading gliomas. Conclusion: Significant correlations were observed between metabolite concentrations and ratios on MRS and APT values. MRS and APT imaging showed comparable diagnostic capability for grading brain tumors, suggesting that both MRS and APT imaging offer potential for quantitatively assessing similar biological characteristics in brain tumors on noncontrast MRI. Level of Evidence: 2. Technical Efficacy: Stage 2. J. MAGN. RESON. IMAGING 2017;46:732–739.
KW - amide proton transfer imaging
KW - chemical exchange saturation transfer
KW - magnetic resonance imaging
KW - magnetic resonance spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=85014305726&partnerID=8YFLogxK
U2 - 10.1002/jmri.25597
DO - 10.1002/jmri.25597
M3 - 学術論文
C2 - 28252822
AN - SCOPUS:85014305726
SN - 1053-1807
VL - 46
SP - 732
EP - 739
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 3
ER -