Cycloartane-type triterpene glycosides anopanins A-C with monoacyldigalactosylglycerols from Anodendron paniculatum

Viet Duc Ho; Thi Nhu Hanh Hoang; Quoc Hung Vo; Van Kiem Phan; Tuan Anh Le; Viet Ty Pham; Minh Hien Nguyen; Takeshi Kodama; Takuya Ito; Hiroyuki Morita; Ain Raal; Thi Hoai Nguyen

doi:10.1016/j.phytochem.2017.09.004

Cycloartane-type triterpene glycosides anopanins A-C with monoacyldigalactosylglycerols from Anodendron paniculatum

Viet Duc Ho, Thi Nhu Hanh Hoang, Quoc Hung Vo, Van Kiem Phan, Tuan Anh Le, Viet Ty Pham, Minh Hien Nguyen, Takeshi Kodama, Takuya Ito, Hiroyuki Morita, Ain Raal^*, Thi Hoai Nguyen

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Three cycloartane-type triterpene glycosides (anopanins A–C), together with three known monoacyldigalactosylglycerols gingerglycolipids A–C and (2S)-1-O-palmitoyl-3-O-[α-D-galactopyranosyl-(1→6)-β-D-galactopyranosyl]-sn-glycerol, were isolated from the aerial parts of Anodendron paniculatum collected in Viet Nam. The chemical structures of the present compounds were elucidated by means of 1D and 2D NMR and HRESIMS spectroscopy, and by comparing to the reported data in the literature. These compounds did not show significant growth inhibitory activities (IC₅₀ > 100 μg/mL) against the tested cancer cell lines LU-1 (lung adenocarcinoma), KB (epidermoid carcinoma), Hep-G2 (hepatoma cancer), MKN-7 (stomach cancer), and SW-480 (colon adenocarcinoma).

Original language	English
Pages (from-to)	113-118
Number of pages	6
Journal	Phytochemistry
Volume	144
DOIs	https://doi.org/10.1016/j.phytochem.2017.09.004
State	Published - 2017/12

Keywords

Anodendron paniculatum
Anopanins A–C
Anticancer activity
Apocynaceae
Cycloartane-type triterpene glycosides

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytochem.2017.09.004

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@article{1213e6886e3d4955a07f37df731a9329,

title = "Cycloartane-type triterpene glycosides anopanins A-C with monoacyldigalactosylglycerols from Anodendron paniculatum",

abstract = "Three cycloartane-type triterpene glycosides (anopanins A–C), together with three known monoacyldigalactosylglycerols gingerglycolipids A–C and (2S)-1-O-palmitoyl-3-O-[α-D-galactopyranosyl-(1→6)-β-D-galactopyranosyl]-sn-glycerol, were isolated from the aerial parts of Anodendron paniculatum collected in Viet Nam. The chemical structures of the present compounds were elucidated by means of 1D and 2D NMR and HRESIMS spectroscopy, and by comparing to the reported data in the literature. These compounds did not show significant growth inhibitory activities (IC50 > 100 μg/mL) against the tested cancer cell lines LU-1 (lung adenocarcinoma), KB (epidermoid carcinoma), Hep-G2 (hepatoma cancer), MKN-7 (stomach cancer), and SW-480 (colon adenocarcinoma).",

keywords = "Anodendron paniculatum, Anopanins A–C, Anticancer activity, Apocynaceae, Cycloartane-type triterpene glycosides",

author = "Ho, {Viet Duc} and Hoang, {Thi Nhu Hanh} and Vo, {Quoc Hung} and Phan, {Van Kiem} and Le, {Tuan Anh} and Pham, {Viet Ty} and Nguyen, {Minh Hien} and Takeshi Kodama and Takuya Ito and Hiroyuki Morita and Ain Raal and Nguyen, {Thi Hoai}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

month = dec,

doi = "10.1016/j.phytochem.2017.09.004",

language = "英語",

volume = "144",

pages = "113--118",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Cycloartane-type triterpene glycosides anopanins A-C with monoacyldigalactosylglycerols from Anodendron paniculatum

AU - Ho, Viet Duc

AU - Hoang, Thi Nhu Hanh

AU - Vo, Quoc Hung

AU - Phan, Van Kiem

AU - Le, Tuan Anh

AU - Pham, Viet Ty

AU - Nguyen, Minh Hien

AU - Kodama, Takeshi

AU - Ito, Takuya

AU - Morita, Hiroyuki

AU - Raal, Ain

AU - Nguyen, Thi Hoai

PY - 2017/12

Y1 - 2017/12

N2 - Three cycloartane-type triterpene glycosides (anopanins A–C), together with three known monoacyldigalactosylglycerols gingerglycolipids A–C and (2S)-1-O-palmitoyl-3-O-[α-D-galactopyranosyl-(1→6)-β-D-galactopyranosyl]-sn-glycerol, were isolated from the aerial parts of Anodendron paniculatum collected in Viet Nam. The chemical structures of the present compounds were elucidated by means of 1D and 2D NMR and HRESIMS spectroscopy, and by comparing to the reported data in the literature. These compounds did not show significant growth inhibitory activities (IC50 > 100 μg/mL) against the tested cancer cell lines LU-1 (lung adenocarcinoma), KB (epidermoid carcinoma), Hep-G2 (hepatoma cancer), MKN-7 (stomach cancer), and SW-480 (colon adenocarcinoma).

AB - Three cycloartane-type triterpene glycosides (anopanins A–C), together with three known monoacyldigalactosylglycerols gingerglycolipids A–C and (2S)-1-O-palmitoyl-3-O-[α-D-galactopyranosyl-(1→6)-β-D-galactopyranosyl]-sn-glycerol, were isolated from the aerial parts of Anodendron paniculatum collected in Viet Nam. The chemical structures of the present compounds were elucidated by means of 1D and 2D NMR and HRESIMS spectroscopy, and by comparing to the reported data in the literature. These compounds did not show significant growth inhibitory activities (IC50 > 100 μg/mL) against the tested cancer cell lines LU-1 (lung adenocarcinoma), KB (epidermoid carcinoma), Hep-G2 (hepatoma cancer), MKN-7 (stomach cancer), and SW-480 (colon adenocarcinoma).

KW - Anodendron paniculatum

KW - Anopanins A–C

KW - Anticancer activity

KW - Apocynaceae

KW - Cycloartane-type triterpene glycosides

UR - http://www.scopus.com/inward/record.url?scp=85029459013&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2017.09.004

DO - 10.1016/j.phytochem.2017.09.004

M3 - 学術論文

C2 - 28923322

AN - SCOPUS:85029459013

SN - 0031-9422

VL - 144

SP - 113

EP - 118

JO - Phytochemistry

JF - Phytochemistry

ER -

Cycloartane-type triterpene glycosides anopanins A-C with monoacyldigalactosylglycerols from Anodendron paniculatum

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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