Clinicopathological features of considerable reduction in androgen receptor expression in sebaceous gland carcinoma of the eyelid

Tatsuya Yunoki; Akio Miyakoshi; Mitsuya Otsuka; Atsushi Hayashi

doi:10.1007/s10792-018-0990-3

Clinicopathological features of considerable reduction in androgen receptor expression in sebaceous gland carcinoma of the eyelid

Tatsuya Yunoki^*, Akio Miyakoshi, Mitsuya Otsuka, Atsushi Hayashi

^*Corresponding author for this work

Ophthalmology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Purpose: This study aimed to evaluate the relationships between androgen receptor (AR) expression and clinicopathologic features of sebaceous gland carcinoma (SGC) of the eyelid. Methods: AR expression was evaluated via immunohistochemistry analysis of surgically derived samples from 11 patients with SGC of the eyelid. Results: The expression of AR was evident in 9 of 11 patients (82%). We divided patients into high AR (7 patients) and low AR (4 patients: 2 patients with low expression and 2 patients with no expression) groups. The low AR group showed significantly greater progression than the high AR group with regard to T category and exhibited a lower grade of differentiation. Conclusion: In patients with SGC of the eyelid, a marked decrease in AR expression may be associated with a poor prognosis. AR may be a prognostic factor and a potential therapeutic target in cases of SGC of the eyelid.

Original language	English
Pages (from-to)	1703-1708
Number of pages	6
Journal	International Ophthalmology
Volume	39
Issue number	8
DOIs	https://doi.org/10.1007/s10792-018-0990-3
State	Published - 2019/08/15

Keywords

Androgen receptor
Differentiation
Immunohistochemistry
Pagetoid spread
Sebaceous gland carcinoma

ASJC Scopus subject areas

Ophthalmology

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10.1007/s10792-018-0990-3

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title = "Clinicopathological features of considerable reduction in androgen receptor expression in sebaceous gland carcinoma of the eyelid",

abstract = "Purpose: This study aimed to evaluate the relationships between androgen receptor (AR) expression and clinicopathologic features of sebaceous gland carcinoma (SGC) of the eyelid. Methods: AR expression was evaluated via immunohistochemistry analysis of surgically derived samples from 11 patients with SGC of the eyelid. Results: The expression of AR was evident in 9 of 11 patients (82%). We divided patients into high AR (7 patients) and low AR (4 patients: 2 patients with low expression and 2 patients with no expression) groups. The low AR group showed significantly greater progression than the high AR group with regard to T category and exhibited a lower grade of differentiation. Conclusion: In patients with SGC of the eyelid, a marked decrease in AR expression may be associated with a poor prognosis. AR may be a prognostic factor and a potential therapeutic target in cases of SGC of the eyelid.",

keywords = "Androgen receptor, Differentiation, Immunohistochemistry, Pagetoid spread, Sebaceous gland carcinoma",

author = "Tatsuya Yunoki and Akio Miyakoshi and Mitsuya Otsuka and Atsushi Hayashi",

note = "Publisher Copyright: {\textcopyright} 2018, Springer Nature B.V.",

year = "2019",

month = aug,

day = "15",

doi = "10.1007/s10792-018-0990-3",

language = "英語",

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TY - JOUR

T1 - Clinicopathological features of considerable reduction in androgen receptor expression in sebaceous gland carcinoma of the eyelid

AU - Yunoki, Tatsuya

AU - Miyakoshi, Akio

AU - Otsuka, Mitsuya

AU - Hayashi, Atsushi

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Purpose: This study aimed to evaluate the relationships between androgen receptor (AR) expression and clinicopathologic features of sebaceous gland carcinoma (SGC) of the eyelid. Methods: AR expression was evaluated via immunohistochemistry analysis of surgically derived samples from 11 patients with SGC of the eyelid. Results: The expression of AR was evident in 9 of 11 patients (82%). We divided patients into high AR (7 patients) and low AR (4 patients: 2 patients with low expression and 2 patients with no expression) groups. The low AR group showed significantly greater progression than the high AR group with regard to T category and exhibited a lower grade of differentiation. Conclusion: In patients with SGC of the eyelid, a marked decrease in AR expression may be associated with a poor prognosis. AR may be a prognostic factor and a potential therapeutic target in cases of SGC of the eyelid.

AB - Purpose: This study aimed to evaluate the relationships between androgen receptor (AR) expression and clinicopathologic features of sebaceous gland carcinoma (SGC) of the eyelid. Methods: AR expression was evaluated via immunohistochemistry analysis of surgically derived samples from 11 patients with SGC of the eyelid. Results: The expression of AR was evident in 9 of 11 patients (82%). We divided patients into high AR (7 patients) and low AR (4 patients: 2 patients with low expression and 2 patients with no expression) groups. The low AR group showed significantly greater progression than the high AR group with regard to T category and exhibited a lower grade of differentiation. Conclusion: In patients with SGC of the eyelid, a marked decrease in AR expression may be associated with a poor prognosis. AR may be a prognostic factor and a potential therapeutic target in cases of SGC of the eyelid.

KW - Androgen receptor

KW - Differentiation

KW - Immunohistochemistry

KW - Pagetoid spread

KW - Sebaceous gland carcinoma

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U2 - 10.1007/s10792-018-0990-3

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SN - 0165-5701

VL - 39

SP - 1703

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JO - International Ophthalmology

JF - International Ophthalmology

IS - 8

ER -

Clinicopathological features of considerable reduction in androgen receptor expression in sebaceous gland carcinoma of the eyelid

Abstract

Keywords

ASJC Scopus subject areas

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