TY - JOUR
T1 - Clinical use of Plasma BNP Concentrations for Diabetic Patients
AU - Kadowaki, Takashi
AU - Iwamoto, Yasuhiko
AU - Sekihara, Hisahiko
AU - Takeda, Nobuakira
AU - Katayama, Shigehiro
AU - Tobe, Kazuyuki
AU - Okada, Terumasa
AU - Kimura, Satoshi
AU - Miura, Junnosuke
AU - Uchigata, Yasuko
AU - Mukasa, Kouji
AU - Inaba, Munemitsu
AU - Himei, Hajime
AU - Nagai, Ryouzou
AU - Akanuma, Yasuo
PY - 2001
Y1 - 2001
N2 - We studied whether plasma BNP concentration measurement was useful in screening for silent ischemia or asymptomatic cardiac dysfunctions in diabetic outpatients in daily clinical practice. Plasma BNP and ANP concentrations in 573 outpatients with diabetes were measured. Plasma BNP concentrations increased with complications of hypertension, heart diseases, cardiac dysfunction, diabetic neuropathy, diabetic nephopathy, and diabetic retinopathy. Plasma BNP also was significantly correlated with NYHA classification, blood pressure, cardio-thoracic-ratio (CTR), SV1 + SV5, 6, interventricular septum thickness, posterior wall thickness, left ventricular mass, and left ventricular mass index. In subjects without heart disease, plasma ANP concentrations showed a correlation with blood glucose, but plasma BNP concentrations did not show such a correlation. Receiver operating characteristic analysis revealed that plasma BNP concentrations showed sensitivity of 62.7% and specificity of 75.0% in detecting heart diseases or cardiac dysfunction. In addition, the result of logistic regression analysis indicated that plasma BNP measurement was the best clinical parameter in the prediction of heart diseases and cardiac dysfunction. Measurement of the plasma BNP concentrations is thus useful in diagnosing heart diseases in diabetic subjects in daily clinical practice.
AB - We studied whether plasma BNP concentration measurement was useful in screening for silent ischemia or asymptomatic cardiac dysfunctions in diabetic outpatients in daily clinical practice. Plasma BNP and ANP concentrations in 573 outpatients with diabetes were measured. Plasma BNP concentrations increased with complications of hypertension, heart diseases, cardiac dysfunction, diabetic neuropathy, diabetic nephopathy, and diabetic retinopathy. Plasma BNP also was significantly correlated with NYHA classification, blood pressure, cardio-thoracic-ratio (CTR), SV1 + SV5, 6, interventricular septum thickness, posterior wall thickness, left ventricular mass, and left ventricular mass index. In subjects without heart disease, plasma ANP concentrations showed a correlation with blood glucose, but plasma BNP concentrations did not show such a correlation. Receiver operating characteristic analysis revealed that plasma BNP concentrations showed sensitivity of 62.7% and specificity of 75.0% in detecting heart diseases or cardiac dysfunction. In addition, the result of logistic regression analysis indicated that plasma BNP measurement was the best clinical parameter in the prediction of heart diseases and cardiac dysfunction. Measurement of the plasma BNP concentrations is thus useful in diagnosing heart diseases in diabetic subjects in daily clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=79952373318&partnerID=8YFLogxK
U2 - 10.11213/tonyobyo1958.44.927
DO - 10.11213/tonyobyo1958.44.927
M3 - 学術論文
AN - SCOPUS:79952373318
SN - 0021-437X
VL - 44
SP - 927
EP - 933
JO - Journal of the Japan Diabetes Society
JF - Journal of the Japan Diabetes Society
IS - 12
ER -
