Chiral Sensing Using Circularly Polarized Luminescence of Bis(phenanthroline dicarboxylic acid) Eu III Complex Induced by Allosteric-type Interaction with Amino Acid Molecules

Munetaka Iwamura*, Mai Fujii, Ayano Yamada, Hikaru Koike, Koichi Nozaki

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

[Eu(pda) 2 ] and [Eu(bda) 2 ] (pda=1,10-phenanthroline-2, 9-dicarboxylic acid; bda=2,2′ bipyridine 5,5′-dicarboxylic acid) have an achiral D 2d structure in crystals. These complexes exhibit circularly polarized luminescence (CPL) in water containing chiral amino acids. In this work, induced CPL of [Eu(pda) 2 ] and [Eu(bda) 2 ] in water solutions containing a mixture of d- and l- amino acids were examined. Plots of g lum values of the induced CPL as a function of mol-fraction of l- and d- arginine reveal that [Eu(pda) 2 ] favors homo-association ([Eu(pda) 2 ] -(l-arginine) 2 or [Eu(pda) 2 ] -(d-arginine) 2 ) over hetero-association {[Eu(pda) 2 ] -(l-arginine)⋅(d-arginine)}. This suggests that association of an arginine molecule induces a structural change in [Eu(pda) 2 ] to promote chiral selective association to another arginine, i.e., homo-allosteric association. On the other hand, the system of [Eu(pda) 2 ] with histidine favors hetero-allosteric association over homo-association. No allosteric effect is recognized in CPL from [Eu(bda) 2 ] .

Original languageEnglish
Pages (from-to)561-567
Number of pages7
JournalChemistry - An Asian Journal
Volume14
Issue number4
DOIs
StatePublished - 2019/02/15

Keywords

  • allosteric effect
  • amino acids
  • chiral sensing
  • circularly polarized luminescence
  • lanthanide complexes

ASJC Scopus subject areas

  • Biochemistry
  • General Chemistry
  • Organic Chemistry

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