Cerebrospinal fluid ATP as a potential biomarker in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes (MELAS)

Takamasa Nukui; Atsushi Matsui; Hideki Niimi; Mamoru Yamamoto; Noriyuki Matsuda; Jin Lan Piao; Kyo Noguchi; Isao Kitajima; Yuji Nakatsuji

doi:10.1016/j.mito.2019.11.001

Cerebrospinal fluid ATP as a potential biomarker in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes (MELAS)

Takamasa Nukui, Atsushi Matsui, Hideki Niimi, Mamoru Yamamoto, Noriyuki Matsuda, Jin Lan Piao, Kyo Noguchi, Isao Kitajima, Yuji Nakatsuji^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is caused by defective oxidative phosphorylation in the cerebral parenchyma, cerebral blood vessels, and leptomeningeal tissue. Although increased blood and cerebrospinal fluid (CSF) lactate level has been used as a diagnostic biomarker in patients with MELAS, no biomarkers reflecting disease activity exist. Since we have developed a highly sensitive ATP assay system using luciferase luminous reaction, we examined CSF ATP in patients with MELAS and found that it negatively correlates with disease activity and that it reflects the efficacy of the treatment. CSF ATP might be a novel disease monitoring marker for MELAS.

Original language	English
Pages (from-to)	145-148
Number of pages	4
Journal	Mitochondrion
Volume	50
DOIs	https://doi.org/10.1016/j.mito.2019.11.001
State	Published - 2020/01

Keywords

ATP
Biomarker
Cerebrospinal fluid
MELAS

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Cell Biology

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10.1016/j.mito.2019.11.001

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title = "Cerebrospinal fluid ATP as a potential biomarker in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes (MELAS)",

abstract = "Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is caused by defective oxidative phosphorylation in the cerebral parenchyma, cerebral blood vessels, and leptomeningeal tissue. Although increased blood and cerebrospinal fluid (CSF) lactate level has been used as a diagnostic biomarker in patients with MELAS, no biomarkers reflecting disease activity exist. Since we have developed a highly sensitive ATP assay system using luciferase luminous reaction, we examined CSF ATP in patients with MELAS and found that it negatively correlates with disease activity and that it reflects the efficacy of the treatment. CSF ATP might be a novel disease monitoring marker for MELAS.",

keywords = "ATP, Biomarker, Cerebrospinal fluid, MELAS",

author = "Takamasa Nukui and Atsushi Matsui and Hideki Niimi and Mamoru Yamamoto and Noriyuki Matsuda and Piao, {Jin Lan} and Kyo Noguchi and Isao Kitajima and Yuji Nakatsuji",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V. and Mitochondria Research Society",

year = "2020",

month = jan,

doi = "10.1016/j.mito.2019.11.001",

language = "英語",

volume = "50",

pages = "145--148",

journal = "Mitochondrion",

issn = "1567-7249",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Cerebrospinal fluid ATP as a potential biomarker in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes (MELAS)

AU - Nukui, Takamasa

AU - Matsui, Atsushi

AU - Niimi, Hideki

AU - Yamamoto, Mamoru

AU - Matsuda, Noriyuki

AU - Piao, Jin Lan

AU - Noguchi, Kyo

AU - Kitajima, Isao

AU - Nakatsuji, Yuji

PY - 2020/1

Y1 - 2020/1

N2 - Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is caused by defective oxidative phosphorylation in the cerebral parenchyma, cerebral blood vessels, and leptomeningeal tissue. Although increased blood and cerebrospinal fluid (CSF) lactate level has been used as a diagnostic biomarker in patients with MELAS, no biomarkers reflecting disease activity exist. Since we have developed a highly sensitive ATP assay system using luciferase luminous reaction, we examined CSF ATP in patients with MELAS and found that it negatively correlates with disease activity and that it reflects the efficacy of the treatment. CSF ATP might be a novel disease monitoring marker for MELAS.

AB - Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is caused by defective oxidative phosphorylation in the cerebral parenchyma, cerebral blood vessels, and leptomeningeal tissue. Although increased blood and cerebrospinal fluid (CSF) lactate level has been used as a diagnostic biomarker in patients with MELAS, no biomarkers reflecting disease activity exist. Since we have developed a highly sensitive ATP assay system using luciferase luminous reaction, we examined CSF ATP in patients with MELAS and found that it negatively correlates with disease activity and that it reflects the efficacy of the treatment. CSF ATP might be a novel disease monitoring marker for MELAS.

KW - ATP

KW - Biomarker

KW - Cerebrospinal fluid

KW - MELAS

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U2 - 10.1016/j.mito.2019.11.001

DO - 10.1016/j.mito.2019.11.001

M3 - 学術論文

C2 - 31756516

AN - SCOPUS:85076116188

SN - 1567-7249

VL - 50

SP - 145

EP - 148

JO - Mitochondrion

JF - Mitochondrion

ER -

Cerebrospinal fluid ATP as a potential biomarker in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes (MELAS)

Abstract

Keywords

ASJC Scopus subject areas

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