Asymmetric synthesis of the four possible fagomine isomers

Hiroki Takahata; Yasunori Banba; Hidekazu Ouchi; Hideo Nemoto; Atsushi Kato; Isao Adachi

doi:10.1021/jo034137u

Asymmetric synthesis of the four possible fagomine isomers

Hiroki Takahata^*, Yasunori Banba, Hidekazu Ouchi, Hideo Nemoto, Atsushi Kato, Isao Adachi

^*Corresponding author for this work

Hospital Pharmacy

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

The asymmetric synthesis of fagomine and its congeners 1-4 has been achieved by catalytic ring-closing metathesis (RCM). The synthesis involved the construction of the piperidene-type chiral building block 5 followed by dihydroxylation, starting from the D-serine-derived Garner aldehyde 6.

Original language	English
Pages (from-to)	3603-3607
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	68
Issue number	9
DOIs	https://doi.org/10.1021/jo034137u
State	Published - 2003/05/02

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo034137u

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@article{b710dee774f8468e99eb7ae837efc0f6,

title = "Asymmetric synthesis of the four possible fagomine isomers",

abstract = "The asymmetric synthesis of fagomine and its congeners 1-4 has been achieved by catalytic ring-closing metathesis (RCM). The synthesis involved the construction of the piperidene-type chiral building block 5 followed by dihydroxylation, starting from the D-serine-derived Garner aldehyde 6.",

author = "Hiroki Takahata and Yasunori Banba and Hidekazu Ouchi and Hideo Nemoto and Atsushi Kato and Isao Adachi",

year = "2003",

month = may,

day = "2",

doi = "10.1021/jo034137u",

language = "英語",

volume = "68",

pages = "3603--3607",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

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T1 - Asymmetric synthesis of the four possible fagomine isomers

AU - Takahata, Hiroki

AU - Banba, Yasunori

AU - Ouchi, Hidekazu

AU - Nemoto, Hideo

AU - Kato, Atsushi

AU - Adachi, Isao

PY - 2003/5/2

Y1 - 2003/5/2

N2 - The asymmetric synthesis of fagomine and its congeners 1-4 has been achieved by catalytic ring-closing metathesis (RCM). The synthesis involved the construction of the piperidene-type chiral building block 5 followed by dihydroxylation, starting from the D-serine-derived Garner aldehyde 6.

AB - The asymmetric synthesis of fagomine and its congeners 1-4 has been achieved by catalytic ring-closing metathesis (RCM). The synthesis involved the construction of the piperidene-type chiral building block 5 followed by dihydroxylation, starting from the D-serine-derived Garner aldehyde 6.

UR - http://www.scopus.com/inward/record.url?scp=0242500286&partnerID=8YFLogxK

U2 - 10.1021/jo034137u

DO - 10.1021/jo034137u

M3 - 学術論文

C2 - 12713367

AN - SCOPUS:0242500286

SN - 0022-3263

VL - 68

SP - 3603

EP - 3607

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 9

ER -

Asymmetric synthesis of the four possible fagomine isomers

Abstract

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