Asymmetric synthesis of 2-substituted 4-chromanones using enzyme-catalyzed reactions

Masashi Kawasaki; Yuka Asano; Kanako Katayama; Akihisa Inoue; Chiho Hiraoka; Hiroko Kakuda; Akira Tanaka; Michimasa Goto; Naoki Toyooka; Tadashi Kometani

doi:10.1016/j.molcatb.2007.12.022

Asymmetric synthesis of 2-substituted 4-chromanones using enzyme-catalyzed reactions

Masashi Kawasaki^*, Yuka Asano, Kanako Katayama, Akihisa Inoue, Chiho Hiraoka, Hiroko Kakuda, Akira Tanaka, Michimasa Goto, Naoki Toyooka, Tadashi Kometani

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

2-Substituted 4-chromanones were synthesized in their optically active forms. The chiral intermediates were obtained via lipase-catalyzed enantioselective reactions. Lipase and esterase were also used for the hydrolysis of ester moieties of the precursors of the target compounds under mild conditions.

Original language	English
Pages (from-to)	93-102
Number of pages	10
Journal	Journal of Molecular Catalysis B: Enzymatic
Volume	54
Issue number	3-4
DOIs	https://doi.org/10.1016/j.molcatb.2007.12.022
State	Published - 2008/08

Keywords

Asymmetric synthesis
Chromanones
Enzyme
Hydrolysis
Resolution

ASJC Scopus subject areas

Catalysis
Bioengineering
Biochemistry
Process Chemistry and Technology

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10.1016/j.molcatb.2007.12.022

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title = "Asymmetric synthesis of 2-substituted 4-chromanones using enzyme-catalyzed reactions",

abstract = "2-Substituted 4-chromanones were synthesized in their optically active forms. The chiral intermediates were obtained via lipase-catalyzed enantioselective reactions. Lipase and esterase were also used for the hydrolysis of ester moieties of the precursors of the target compounds under mild conditions.",

keywords = "Asymmetric synthesis, Chromanones, Enzyme, Hydrolysis, Resolution",

author = "Masashi Kawasaki and Yuka Asano and Kanako Katayama and Akihisa Inoue and Chiho Hiraoka and Hiroko Kakuda and Akira Tanaka and Michimasa Goto and Naoki Toyooka and Tadashi Kometani",

year = "2008",

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doi = "10.1016/j.molcatb.2007.12.022",

language = "英語",

volume = "54",

pages = "93--102",

journal = "Journal of Molecular Catalysis B: Enzymatic",

issn = "1381-1177",

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number = "3-4",

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TY - JOUR

T1 - Asymmetric synthesis of 2-substituted 4-chromanones using enzyme-catalyzed reactions

AU - Kawasaki, Masashi

AU - Asano, Yuka

AU - Katayama, Kanako

AU - Inoue, Akihisa

AU - Hiraoka, Chiho

AU - Kakuda, Hiroko

AU - Tanaka, Akira

AU - Goto, Michimasa

AU - Toyooka, Naoki

AU - Kometani, Tadashi

PY - 2008/8

Y1 - 2008/8

N2 - 2-Substituted 4-chromanones were synthesized in their optically active forms. The chiral intermediates were obtained via lipase-catalyzed enantioselective reactions. Lipase and esterase were also used for the hydrolysis of ester moieties of the precursors of the target compounds under mild conditions.

AB - 2-Substituted 4-chromanones were synthesized in their optically active forms. The chiral intermediates were obtained via lipase-catalyzed enantioselective reactions. Lipase and esterase were also used for the hydrolysis of ester moieties of the precursors of the target compounds under mild conditions.

KW - Asymmetric synthesis

KW - Chromanones

KW - Enzyme

KW - Hydrolysis

KW - Resolution

UR - http://www.scopus.com/inward/record.url?scp=47549109648&partnerID=8YFLogxK

U2 - 10.1016/j.molcatb.2007.12.022

DO - 10.1016/j.molcatb.2007.12.022

M3 - 学術論文

AN - SCOPUS:47549109648

SN - 1381-1177

VL - 54

SP - 93

EP - 102

JO - Journal of Molecular Catalysis B: Enzymatic

JF - Journal of Molecular Catalysis B: Enzymatic

IS - 3-4

ER -

Asymmetric synthesis of 2-substituted 4-chromanones using enzyme-catalyzed reactions

Abstract

Keywords

ASJC Scopus subject areas

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