Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.

Yasuhiro Igarashi; Martha E. Trujillo; Eustoquio Martínez-Molina; Saeko Yanase; Satoshi Miyanaga; Takamasa Obata; Hiroaki Sakurai; Ikuo Saiki; Tsuyoshi Fujita; Tamotsu Furumai

doi:10.1016/j.bmcl.2007.04.039

Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.

Yasuhiro Igarashi^*, Martha E. Trujillo, Eustoquio Martínez-Molina, Saeko Yanase, Satoshi Miyanaga, Takamasa Obata, Hiroaki Sakurai, Ikuo Saiki, Tsuyoshi Fujita, Tamotsu Furumai

^*Corresponding author for this work

Cancer Cell Biology

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

Two novel anthraquinones, lupinacidins A (1) and B (2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth.

Original language	English
Pages (from-to)	3702-3705
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	13
DOIs	https://doi.org/10.1016/j.bmcl.2007.04.039
State	Published - 2007/07/01

Keywords

Antitumor
Invasion
Lupinacidin
Micromonospora

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2007.04.039

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title = "Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.",

abstract = "Two novel anthraquinones, lupinacidins A (1) and B (2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth.",

keywords = "Antitumor, Invasion, Lupinacidin, Micromonospora",

author = "Yasuhiro Igarashi and Trujillo, {Martha E.} and Eustoquio Mart{\'i}nez-Molina and Saeko Yanase and Satoshi Miyanaga and Takamasa Obata and Hiroaki Sakurai and Ikuo Saiki and Tsuyoshi Fujita and Tamotsu Furumai",

note = "Funding Information: This work was partly supported by Nagase Science and Technology Foundation. The authors thank Dr. Hiroyuki Watanabe at Varian Technology, Japan, for the measurement of HMBC spectra. M. E. Trujillo and E. Mart{\'i}nez-Molina acknowledge financial support of the Ministerio de Educac{\'i}on y Ciencia (MEC) under the Project CGL2006-06988/BOS.",

year = "2007",

month = jul,

day = "1",

doi = "10.1016/j.bmcl.2007.04.039",

language = "英語",

volume = "17",

pages = "3702--3705",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.

AU - Igarashi, Yasuhiro

AU - Trujillo, Martha E.

AU - Martínez-Molina, Eustoquio

AU - Yanase, Saeko

AU - Miyanaga, Satoshi

AU - Obata, Takamasa

AU - Sakurai, Hiroaki

AU - Saiki, Ikuo

AU - Fujita, Tsuyoshi

AU - Furumai, Tamotsu

N1 - Funding Information: This work was partly supported by Nagase Science and Technology Foundation. The authors thank Dr. Hiroyuki Watanabe at Varian Technology, Japan, for the measurement of HMBC spectra. M. E. Trujillo and E. Martínez-Molina acknowledge financial support of the Ministerio de Educacíon y Ciencia (MEC) under the Project CGL2006-06988/BOS.

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Two novel anthraquinones, lupinacidins A (1) and B (2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth.

AB - Two novel anthraquinones, lupinacidins A (1) and B (2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth.

KW - Antitumor

KW - Invasion

KW - Lupinacidin

KW - Micromonospora

UR - http://www.scopus.com/inward/record.url?scp=34250176599&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2007.04.039

DO - 10.1016/j.bmcl.2007.04.039

M3 - 学術論文

C2 - 17475486

AN - SCOPUS:34250176599

SN - 0960-894X

VL - 17

SP - 3702

EP - 3705

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.

Abstract

Keywords

ASJC Scopus subject areas

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