Abstract
A 45-year-old Japanese man was referred to our hospital because of hyperglycemia despite the administration of as much as 120 U/day of human insulin. He had no history of injecting animal insulin. Free insulin was below 5 μU/ml, but a high titer of total insulin (about 3,000 μU/ml) was observed, suggesting the presence of antibodies against human insulin. Scatchard analysis showed an increased insulin binding capacity in the plasma characterized by a higher affinity for insulin. He was successfully treated by cessation of insulin administration. A Scatchard analysis series showed that a reduction in the insulin binding capacity of antibodies paralleled the improvement in glycemic control.
Original language | English |
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Pages (from-to) | 143-145 |
Number of pages | 3 |
Journal | Internal Medicine |
Volume | 39 |
Issue number | 2 |
DOIs | |
State | Published - 2000/02 |
Keywords
- Anti-insulin antibody
- Scatchard analysis
ASJC Scopus subject areas
- Internal Medicine