Antibody-mediated insulin resistance treated by cessation of insulin administration

Kazuo Hara, Kazuyuki Tobe, Yasuko Uchigata, Makoto Nakazono, Kazuki Yasuda, Yasuo Terauchi, Yasuhiko Iwamoto, Yasuo Akanuma, Satoshi Kimura, Takashi Kadowaki*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

A 45-year-old Japanese man was referred to our hospital because of hyperglycemia despite the administration of as much as 120 U/day of human insulin. He had no history of injecting animal insulin. Free insulin was below 5 μU/ml, but a high titer of total insulin (about 3,000 μU/ml) was observed, suggesting the presence of antibodies against human insulin. Scatchard analysis showed an increased insulin binding capacity in the plasma characterized by a higher affinity for insulin. He was successfully treated by cessation of insulin administration. A Scatchard analysis series showed that a reduction in the insulin binding capacity of antibodies paralleled the improvement in glycemic control.

Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalInternal Medicine
Volume39
Issue number2
DOIs
StatePublished - 2000/02

Keywords

  • Anti-insulin antibody
  • Scatchard analysis

ASJC Scopus subject areas

  • Internal Medicine

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