Anti-inflammatory activities of isopimara-8(9),15-diene diterpenoids and mode of action of kaempulchraols B–D from Kaempferia pulchra rhizomes

Nwet Nwet Win, Besse Hardianti, Hla Ngwe, Yoshihiro Hayakawa*, Hiroyuki Morita

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Kaempulchraols B–D (2–4), isopimara-8(9),15-diene diterpenoids isolated from Kaempferia pulchra rhizomes collected in Myanmar, were identified as potent NF-κB inhibitors. These compounds were also effective as NO inhibitory agents, with IC50 values of 47.69, 44.97, and 38.17 μM, respectively, without showing any cytotoxicity against LPS-induced RAW264.7 cells. Investigations of the mechanisms of action of 2–4 revealed that they inhibit the NF-κB-mediated transactivation of a luciferase reporter gene, IL-6 production, and COX-2 expression, with an effective dose of 25 μM. Thus, isopimarane diterpenoids are suggested to be potent inhibitors of NF-κB pathways and could be further explored as potential anti-inflammatory lead compounds.

Original languageEnglish
Pages (from-to)487-494
Number of pages8
JournalNatural Medicines
Volume74
Issue number2
DOIs
StatePublished - 2020/03/01

Keywords

  • Isopimarane diterpenoids
  • Kaempferia pulchra
  • Kaempulchraols
  • NF-κB inhibitors

ASJC Scopus subject areas

  • Molecular Medicine

Fingerprint

Dive into the research topics of 'Anti-inflammatory activities of isopimara-8(9),15-diene diterpenoids and mode of action of kaempulchraols B–D from Kaempferia pulchra rhizomes'. Together they form a unique fingerprint.

Cite this