Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human

K. Huebner; A. Ar-Rushdi; C. A. Griffin; M. Isobe; C. Kozak; B. S. Emanuel; L. Nagarajan; J. L. Cleveland; T. I. Bonner; M. D. Goldsborough

doi:10.1073/pnas.83.11.3934

Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human

K. Huebner, A. Ar-Rushdi, C. A. Griffin, M. Isobe, C. Kozak, B. S. Emanuel, L. Nagarajan, J. L. Cleveland, T. I. Bonner, M. D. Goldsborough

Life Sciences and Bioengineering

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Abstract

Murine and human cDNAs, related to but distinct from c-raf-1, have been isolated and designated mA-raf and hA-raf, respectively. The mA-raf and hA-raf cDNAs detect the same murine and human fragments in Southern blots of restriction enzyme-cleaved murine and human cellular DNA. The murine restriction enzyme fragments homologous to mA-raf cDNA cosegregate with mouse chromosome X in a panel of Chinese hamster-mouse hybrid cells, thus localizing the mA-raf locus to mouse chromosome X. Two independently segregating loci, detected by the hA-raf cDNA (or mA-raf cDNA), hA-raf-1 and hA-raf-2, are located on human chromosomes X and 7, respectively. The mA-raf locus and the hA-raf-1 locus are actively transcribed in several mouse and human cell lines.

Original language	English
Pages (from-to)	3934-3938
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	83
Issue number	11
DOIs	https://doi.org/10.1073/pnas.83.11.3934
State	Published - 1986

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Huebner, K., Ar-Rushdi, A., Griffin, C. A., Isobe, M., Kozak, C., Emanuel, B. S., Nagarajan, L., Cleveland, J. L., Bonner, T. I., & Goldsborough, M. D. (1986). Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human. Proceedings of the National Academy of Sciences of the United States of America, 83(11), 3934-3938. https://doi.org/10.1073/pnas.83.11.3934

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title = "Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human",

abstract = "Murine and human cDNAs, related to but distinct from c-raf-1, have been isolated and designated mA-raf and hA-raf, respectively. The mA-raf and hA-raf cDNAs detect the same murine and human fragments in Southern blots of restriction enzyme-cleaved murine and human cellular DNA. The murine restriction enzyme fragments homologous to mA-raf cDNA cosegregate with mouse chromosome X in a panel of Chinese hamster-mouse hybrid cells, thus localizing the mA-raf locus to mouse chromosome X. Two independently segregating loci, detected by the hA-raf cDNA (or mA-raf cDNA), hA-raf-1 and hA-raf-2, are located on human chromosomes X and 7, respectively. The mA-raf locus and the hA-raf-1 locus are actively transcribed in several mouse and human cell lines.",

author = "K. Huebner and A. Ar-Rushdi and Griffin, {C. A.} and M. Isobe and C. Kozak and Emanuel, {B. S.} and L. Nagarajan and Cleveland, {J. L.} and Bonner, {T. I.} and Goldsborough, {M. D.}",

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doi = "10.1073/pnas.83.11.3934",

language = "英語",

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Huebner, K, Ar-Rushdi, A, Griffin, CA, Isobe, M, Kozak, C, Emanuel, BS, Nagarajan, L, Cleveland, JL, Bonner, TI & Goldsborough, MD 1986, 'Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human', Proceedings of the National Academy of Sciences of the United States of America, vol. 83, no. 11, pp. 3934-3938. https://doi.org/10.1073/pnas.83.11.3934

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T1 - Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human

AU - Huebner, K.

AU - Ar-Rushdi, A.

AU - Griffin, C. A.

AU - Isobe, M.

AU - Kozak, C.

AU - Emanuel, B. S.

AU - Nagarajan, L.

AU - Cleveland, J. L.

AU - Bonner, T. I.

AU - Goldsborough, M. D.

PY - 1986

Y1 - 1986

N2 - Murine and human cDNAs, related to but distinct from c-raf-1, have been isolated and designated mA-raf and hA-raf, respectively. The mA-raf and hA-raf cDNAs detect the same murine and human fragments in Southern blots of restriction enzyme-cleaved murine and human cellular DNA. The murine restriction enzyme fragments homologous to mA-raf cDNA cosegregate with mouse chromosome X in a panel of Chinese hamster-mouse hybrid cells, thus localizing the mA-raf locus to mouse chromosome X. Two independently segregating loci, detected by the hA-raf cDNA (or mA-raf cDNA), hA-raf-1 and hA-raf-2, are located on human chromosomes X and 7, respectively. The mA-raf locus and the hA-raf-1 locus are actively transcribed in several mouse and human cell lines.

AB - Murine and human cDNAs, related to but distinct from c-raf-1, have been isolated and designated mA-raf and hA-raf, respectively. The mA-raf and hA-raf cDNAs detect the same murine and human fragments in Southern blots of restriction enzyme-cleaved murine and human cellular DNA. The murine restriction enzyme fragments homologous to mA-raf cDNA cosegregate with mouse chromosome X in a panel of Chinese hamster-mouse hybrid cells, thus localizing the mA-raf locus to mouse chromosome X. Two independently segregating loci, detected by the hA-raf cDNA (or mA-raf cDNA), hA-raf-1 and hA-raf-2, are located on human chromosomes X and 7, respectively. The mA-raf locus and the hA-raf-1 locus are actively transcribed in several mouse and human cell lines.

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JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 11

ER -

Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human

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