A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy

Eiji Kobayashi; Hiroyuki Kishi; Atsushi Muraguchi

doi:10.4161/onci.27258

A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy

Eiji Kobayashi, Hiroyuki Kishi^*, Atsushi Muraguchi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

T-cell receptor (TCR)-based gene immunotherapy has emerged as a promising approach for the treatment of multiple malignancies. We have recently reported an efficient system for the cloning and functional evaluation of TCR-coding cDNAs. This system, which we named hTEC10, allows for the determination of TCR antigen specificity in less than 10 days, and may therefore constitute a fast and powerful platform for the development of new TCR-based anticancer therapies.

Original language	English
Article number	e27258
Journal	OncoImmunology
Volume	3
Issue number	1
DOIs	https://doi.org/10.4161/onci.27258
State	Published - 2014

Keywords

Gene therapy
HTEC10
Single-cell RT-PCR
T-cell receptor

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.27258

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title = "A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy",

abstract = "T-cell receptor (TCR)-based gene immunotherapy has emerged as a promising approach for the treatment of multiple malignancies. We have recently reported an efficient system for the cloning and functional evaluation of TCR-coding cDNAs. This system, which we named hTEC10, allows for the determination of TCR antigen specificity in less than 10 days, and may therefore constitute a fast and powerful platform for the development of new TCR-based anticancer therapies.",

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AU - Kishi, Hiroyuki

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AB - T-cell receptor (TCR)-based gene immunotherapy has emerged as a promising approach for the treatment of multiple malignancies. We have recently reported an efficient system for the cloning and functional evaluation of TCR-coding cDNAs. This system, which we named hTEC10, allows for the determination of TCR antigen specificity in less than 10 days, and may therefore constitute a fast and powerful platform for the development of new TCR-based anticancer therapies.

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KW - HTEC10

KW - Single-cell RT-PCR

KW - T-cell receptor

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A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy

Abstract

Keywords

ASJC Scopus subject areas

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