Abstract
A housekeeping basolateral Cl- channel in rabbit gastric parietal cells (0.3-0.4 pS) is closed by an intracellular application of GTP gamma S. Here, we found a novel GTP gamma S-dependent regulatory mechanism, in which GTP gamma S stimulates intracellular superoxide (O2-) production and the O2- acts as a messenger in the closure of the Cl- channel. Other oxygen species such as .OH and H2O2 were not involved in the closing mechanism.
| Original language | English |
|---|---|
| Pages (from-to) | S301-302 |
| Journal | Japanese Journal of Physiology |
| Volume | 44 Suppl 2 |
| State | Published - 1994 |
ASJC Scopus subject areas
- Physiology