A new tetrahydrofuran lignan from premna serratifolia wood

So Yeun Woo; Chin Piow Wong; Nwet Nwet Win; Shotaro Hoshino; Prema; Hla Ngwe; Ikuro Abe; Hiroyuki Morita

doi:10.1177/1934578X1901400130

A new tetrahydrofuran lignan from premna serratifolia wood

So Yeun Woo, Chin Piow Wong, Nwet Nwet Win, Shotaro Hoshino, Prema, Hla Ngwe, Ikuro Abe, Hiroyuki Morita

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Phytochemical investigation of the CHCl3 extract of Premna serratifolia (syn: P. integrifolia) wood collected in Myanmar led to the isolation of a new tetrahydrofuran type lignan, 7,9-dihydroxydolichanthin B (1), together with two known triterpenoids, oleanonic acid (2) and (2?, 3?)-dihydroxyolean-12-en- 28-oic acid (3). The structure of the new compound was determined using various spectroscopic techniques, mainly 1D- And 2D-NMR, HRESIMS, IR, and optical rotation, and by comparisons with the reported literatures. Compounds 1?3 had anti-melanin deposition activities against IBMX and ?-MSH induced B16-F10 mouse melanoma cell line with IC50 values of 18.4, 17.7 and 11.2 ?M, respectively. However, 2 exhibited cytotoxicity at concentrations above 50 ?M.

Original language	English
Pages (from-to)	113-116
Number of pages	4
Journal	Natural Product Communications
Volume	14
Issue number	1
DOIs	https://doi.org/10.1177/1934578X1901400130
State	Published - 2019/01

Keywords

Anti-melanin deposition activity
Lignan
Myanmar
Premna serratifolia
Triterpenoids

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Plant Science
Complementary and alternative medicine

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10.1177/1934578X1901400130

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title = "A new tetrahydrofuran lignan from premna serratifolia wood",

abstract = "Phytochemical investigation of the CHCl3 extract of Premna serratifolia (syn: P. integrifolia) wood collected in Myanmar led to the isolation of a new tetrahydrofuran type lignan, 7,9-dihydroxydolichanthin B (1), together with two known triterpenoids, oleanonic acid (2) and (2?, 3?)-dihydroxyolean-12-en- 28-oic acid (3). The structure of the new compound was determined using various spectroscopic techniques, mainly 1D- And 2D-NMR, HRESIMS, IR, and optical rotation, and by comparisons with the reported literatures. Compounds 1?3 had anti-melanin deposition activities against IBMX and ?-MSH induced B16-F10 mouse melanoma cell line with IC50 values of 18.4, 17.7 and 11.2 ?M, respectively. However, 2 exhibited cytotoxicity at concentrations above 50 ?M.",

keywords = "Anti-melanin deposition activity, Lignan, Myanmar, Premna serratifolia, Triterpenoids",

author = "Woo, {So Yeun} and Wong, {Chin Piow} and Win, {Nwet Nwet} and Shotaro Hoshino and Prema and Hla Ngwe and Ikuro Abe and Hiroyuki Morita",

year = "2019",

month = jan,

doi = "10.1177/1934578X1901400130",

language = "英語",

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T1 - A new tetrahydrofuran lignan from premna serratifolia wood

AU - Woo, So Yeun

AU - Wong, Chin Piow

AU - Win, Nwet Nwet

AU - Hoshino, Shotaro

AU - Prema,

AU - Ngwe, Hla

AU - Abe, Ikuro

AU - Morita, Hiroyuki

PY - 2019/1

Y1 - 2019/1

N2 - Phytochemical investigation of the CHCl3 extract of Premna serratifolia (syn: P. integrifolia) wood collected in Myanmar led to the isolation of a new tetrahydrofuran type lignan, 7,9-dihydroxydolichanthin B (1), together with two known triterpenoids, oleanonic acid (2) and (2?, 3?)-dihydroxyolean-12-en- 28-oic acid (3). The structure of the new compound was determined using various spectroscopic techniques, mainly 1D- And 2D-NMR, HRESIMS, IR, and optical rotation, and by comparisons with the reported literatures. Compounds 1?3 had anti-melanin deposition activities against IBMX and ?-MSH induced B16-F10 mouse melanoma cell line with IC50 values of 18.4, 17.7 and 11.2 ?M, respectively. However, 2 exhibited cytotoxicity at concentrations above 50 ?M.

AB - Phytochemical investigation of the CHCl3 extract of Premna serratifolia (syn: P. integrifolia) wood collected in Myanmar led to the isolation of a new tetrahydrofuran type lignan, 7,9-dihydroxydolichanthin B (1), together with two known triterpenoids, oleanonic acid (2) and (2?, 3?)-dihydroxyolean-12-en- 28-oic acid (3). The structure of the new compound was determined using various spectroscopic techniques, mainly 1D- And 2D-NMR, HRESIMS, IR, and optical rotation, and by comparisons with the reported literatures. Compounds 1?3 had anti-melanin deposition activities against IBMX and ?-MSH induced B16-F10 mouse melanoma cell line with IC50 values of 18.4, 17.7 and 11.2 ?M, respectively. However, 2 exhibited cytotoxicity at concentrations above 50 ?M.

KW - Anti-melanin deposition activity

KW - Lignan

KW - Myanmar

KW - Premna serratifolia

KW - Triterpenoids

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DO - 10.1177/1934578X1901400130

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SP - 113

EP - 116

JO - Natural Product Communications

JF - Natural Product Communications

IS - 1

ER -

A new tetrahydrofuran lignan from premna serratifolia wood

Abstract

Keywords

ASJC Scopus subject areas

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