A new sterol from the Vietnamese marine sponge Xestospongia testudinaria and its biological activities

Hien Minh Nguyen; Takuya Ito; Nwet Nwet Win; Hung Quoc Vo; Hoai Thi Nguyen; Hiroyuki Morita

doi:10.1080/14786419.2018.1465057

A new sterol from the Vietnamese marine sponge Xestospongia testudinaria and its biological activities

Hien Minh Nguyen, Takuya Ito^*, Nwet Nwet Win, Hung Quoc Vo, Hoai Thi Nguyen, Hiroyuki Morita

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A new sterol, langcosterol A (1), together with two known sterols 2 and 3, were isolated from the marine sponge Xestospongia testudinaria collected in Vietnam. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses and comparisons with published data. The new compound 1 and the known compound 3 exhibited moderate cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervical cancer) and a human normal cell line (WI-38 fibroblast), with IC₅₀ values ranging from 29.0 to 68.0 μM.

Original language	English
Pages (from-to)	1175-1181
Number of pages	7
Journal	Natural Product Research
Volume	33
Issue number	8
DOIs	https://doi.org/10.1080/14786419.2018.1465057
State	Published - 2019/04/18

Keywords

Vietnam
Xestospongia testudinaria
antibacterial activity
cytotoxicity
sterol

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

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10.1080/14786419.2018.1465057

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title = "A new sterol from the Vietnamese marine sponge Xestospongia testudinaria and its biological activities",

abstract = "A new sterol, langcosterol A (1), together with two known sterols 2 and 3, were isolated from the marine sponge Xestospongia testudinaria collected in Vietnam. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses and comparisons with published data. The new compound 1 and the known compound 3 exhibited moderate cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervical cancer) and a human normal cell line (WI-38 fibroblast), with IC50 values ranging from 29.0 to 68.0 μM.",

keywords = "Vietnam, Xestospongia testudinaria, antibacterial activity, cytotoxicity, sterol",

author = "Nguyen, {Hien Minh} and Takuya Ito and Win, {Nwet Nwet} and Vo, {Hung Quoc} and Nguyen, {Hoai Thi} and Hiroyuki Morita",

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doi = "10.1080/14786419.2018.1465057",

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T1 - A new sterol from the Vietnamese marine sponge Xestospongia testudinaria and its biological activities

AU - Nguyen, Hien Minh

AU - Ito, Takuya

AU - Win, Nwet Nwet

AU - Vo, Hung Quoc

AU - Nguyen, Hoai Thi

AU - Morita, Hiroyuki

PY - 2019/4/18

Y1 - 2019/4/18

N2 - A new sterol, langcosterol A (1), together with two known sterols 2 and 3, were isolated from the marine sponge Xestospongia testudinaria collected in Vietnam. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses and comparisons with published data. The new compound 1 and the known compound 3 exhibited moderate cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervical cancer) and a human normal cell line (WI-38 fibroblast), with IC50 values ranging from 29.0 to 68.0 μM.

AB - A new sterol, langcosterol A (1), together with two known sterols 2 and 3, were isolated from the marine sponge Xestospongia testudinaria collected in Vietnam. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses and comparisons with published data. The new compound 1 and the known compound 3 exhibited moderate cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervical cancer) and a human normal cell line (WI-38 fibroblast), with IC50 values ranging from 29.0 to 68.0 μM.

KW - Vietnam

KW - Xestospongia testudinaria

KW - antibacterial activity

KW - cytotoxicity

KW - sterol

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AN - SCOPUS:85045838692

SN - 1478-6419

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JO - Natural Product Research

JF - Natural Product Research

IS - 8

ER -

A new sterol from the Vietnamese marine sponge Xestospongia testudinaria and its biological activities

Abstract

Keywords

ASJC Scopus subject areas

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