A New Isoflavanol from the Fruits of Kotschya strigosa (Fabaceae)

Maurice D. Awouafack*, Roland T. Tchuenguem, Takuya Ito, Jean P. Dzoyem, Pierre Tane, Hiroyuki Morita

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The phytochemical investigation of the MeOH extract from fruits of Kotschya strigosa using repeated normal and reversed-phase column chromatography and Sephadex LH-20 chromatography led to the isolation and characterization of a new isoflavanol, named kotstrigoisoflavanol (1), together with three known compounds, diosmetin (2), β-sitosterol (3), and the 3-O-β-d-glucopyranoside of β-sitosterol (4). The antioxidant activity of crude extract, 1, and 2 was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPḢ) method. The crude extract (IC50 61.7 ± 0.2 μg/ml) and 2 (IC50 70.2 ± 0.1 μg/ml) showed moderate antioxidant activities, while 1 was weakly active (IC50 153.1 ± 0.1 μg/ml), as compared with the standard reference l-ascorbic acid (IC50 21.9 ± 0.0 μg/ml).

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalHelvetica Chimica Acta
Volume99
Issue number4
DOIs
StatePublished - 2016/04/01

Keywords

  • Antioxidant activity
  • Isoflavanol
  • Kotschya strigosa
  • Kotstrigoisoflavanol

ASJC Scopus subject areas

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint

Dive into the research topics of 'A New Isoflavanol from the Fruits of Kotschya strigosa (Fabaceae)'. Together they form a unique fingerprint.

Cite this