A new iridoid from the aerial parts of Hedyotis pilulifera

Nguyen Thi Hoai; Ho Viet Duc; Nguyen Dinh Quynh Phu; Takeshi Kodama; Takuya Ito; Hiroyuki Morita

doi:10.1177/1934578x1601100311

A new iridoid from the aerial parts of Hedyotis pilulifera

Nguyen Thi Hoai, Ho Viet Duc, Nguyen Dinh Quynh Phu, Takeshi Kodama, Takuya Ito, Hiroyuki Morita

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A new iridoid, 10-acetylborreriagenin (1), and five known iridoid glycosides (2-6), were isolated from the aerial parts of Hedyotis pilulifera. Their structures were elucidated by spectral analyses, including 1D- and 2D-NMR, and HR-ESI-MS, and comparisons with the NMR data reported in the literature. The isolated compounds 1-6 were tested against six bacterial species. Among them, 10-acetylborreriagenin (1) showed antibacterial activity against Staphylococcus aureus, with an MIC value of 100 μg/mL.

Original language	English
Pages (from-to)	365-367
Number of pages	3
Journal	Natural Product Communications
Volume	11
Issue number	3
DOIs	https://doi.org/10.1177/1934578x1601100311
State	Published - 2016/03

Keywords

10-Acetylborreriagenin
Antibacterial activity
Hedyotis pilulifera
Iridoid

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Plant Science
Complementary and alternative medicine

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title = "A new iridoid from the aerial parts of Hedyotis pilulifera",

abstract = "A new iridoid, 10-acetylborreriagenin (1), and five known iridoid glycosides (2-6), were isolated from the aerial parts of Hedyotis pilulifera. Their structures were elucidated by spectral analyses, including 1D- and 2D-NMR, and HR-ESI-MS, and comparisons with the NMR data reported in the literature. The isolated compounds 1-6 were tested against six bacterial species. Among them, 10-acetylborreriagenin (1) showed antibacterial activity against Staphylococcus aureus, with an MIC value of 100 μg/mL.",

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author = "Hoai, {Nguyen Thi} and Duc, {Ho Viet} and Phu, {Nguyen Dinh Quynh} and Takeshi Kodama and Takuya Ito and Hiroyuki Morita",

year = "2016",

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T1 - A new iridoid from the aerial parts of Hedyotis pilulifera

AU - Hoai, Nguyen Thi

AU - Duc, Ho Viet

AU - Phu, Nguyen Dinh Quynh

AU - Kodama, Takeshi

AU - Ito, Takuya

AU - Morita, Hiroyuki

PY - 2016/3

Y1 - 2016/3

N2 - A new iridoid, 10-acetylborreriagenin (1), and five known iridoid glycosides (2-6), were isolated from the aerial parts of Hedyotis pilulifera. Their structures were elucidated by spectral analyses, including 1D- and 2D-NMR, and HR-ESI-MS, and comparisons with the NMR data reported in the literature. The isolated compounds 1-6 were tested against six bacterial species. Among them, 10-acetylborreriagenin (1) showed antibacterial activity against Staphylococcus aureus, with an MIC value of 100 μg/mL.

AB - A new iridoid, 10-acetylborreriagenin (1), and five known iridoid glycosides (2-6), were isolated from the aerial parts of Hedyotis pilulifera. Their structures were elucidated by spectral analyses, including 1D- and 2D-NMR, and HR-ESI-MS, and comparisons with the NMR data reported in the literature. The isolated compounds 1-6 were tested against six bacterial species. Among them, 10-acetylborreriagenin (1) showed antibacterial activity against Staphylococcus aureus, with an MIC value of 100 μg/mL.

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KW - Antibacterial activity

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A new iridoid from the aerial parts of Hedyotis pilulifera

Abstract

Keywords

ASJC Scopus subject areas

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