A new ionone derivative from the leaves of Picrasma quassioides

Chang Liu; Rong Rong Cheng; Zhu zhen Han; Ying bo Yang; Yue Zhou; Li Yang; Zheng Tao Wang

doi:10.1080/10286020.2018.1464561

A new ionone derivative from the leaves of Picrasma quassioides

Chang Liu, Rong Rong Cheng, Zhu zhen Han, Ying bo Yang, Yue Zhou, Li Yang, Zheng Tao Wang^*

^*Corresponding author for this work

Cancer Cell Biology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Nigakialcohol A (1), as unusual cyclization ionone derivative, together with eight known ones (2–9), were isolated from the leaves of Picrasma quassioides (D. Don) Benn (Simaroubaceae). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. Compound 2 showed a weak inhibitory effect on NO production at non-cytotoxic concentration (100 μM) with inhibitory rate of 59%, and thus it should be regarded as potential anti-inflammatory agents.

Original language	English
Pages (from-to)	652-658
Number of pages	7
Journal	Journal of Asian Natural Products Research
Volume	21
Issue number	7
DOIs	https://doi.org/10.1080/10286020.2018.1464561
State	Published - 2019/07/03

Keywords

Picrasma quassioides
Simaroubaceae
anti-inflammatory
ionone derivatives

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1080/10286020.2018.1464561

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title = "A new ionone derivative from the leaves of Picrasma quassioides",

abstract = "Nigakialcohol A (1), as unusual cyclization ionone derivative, together with eight known ones (2–9), were isolated from the leaves of Picrasma quassioides (D. Don) Benn (Simaroubaceae). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. Compound 2 showed a weak inhibitory effect on NO production at non-cytotoxic concentration (100 μM) with inhibitory rate of 59%, and thus it should be regarded as potential anti-inflammatory agents.",

keywords = "Picrasma quassioides, Simaroubaceae, anti-inflammatory, ionone derivatives",

author = "Chang Liu and Cheng, {Rong Rong} and Han, {Zhu zhen} and Yang, {Ying bo} and Yue Zhou and Li Yang and Wang, {Zheng Tao}",

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year = "2019",

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doi = "10.1080/10286020.2018.1464561",

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T1 - A new ionone derivative from the leaves of Picrasma quassioides

AU - Liu, Chang

AU - Cheng, Rong Rong

AU - Han, Zhu zhen

AU - Yang, Ying bo

AU - Zhou, Yue

AU - Yang, Li

AU - Wang, Zheng Tao

PY - 2019/7/3

Y1 - 2019/7/3

N2 - Nigakialcohol A (1), as unusual cyclization ionone derivative, together with eight known ones (2–9), were isolated from the leaves of Picrasma quassioides (D. Don) Benn (Simaroubaceae). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. Compound 2 showed a weak inhibitory effect on NO production at non-cytotoxic concentration (100 μM) with inhibitory rate of 59%, and thus it should be regarded as potential anti-inflammatory agents.

AB - Nigakialcohol A (1), as unusual cyclization ionone derivative, together with eight known ones (2–9), were isolated from the leaves of Picrasma quassioides (D. Don) Benn (Simaroubaceae). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. Compound 2 showed a weak inhibitory effect on NO production at non-cytotoxic concentration (100 μM) with inhibitory rate of 59%, and thus it should be regarded as potential anti-inflammatory agents.

KW - Picrasma quassioides

KW - Simaroubaceae

KW - anti-inflammatory

KW - ionone derivatives

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U2 - 10.1080/10286020.2018.1464561

DO - 10.1080/10286020.2018.1464561

M3 - 学術論文

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AN - SCOPUS:85046495113

SN - 1028-6020

VL - 21

SP - 652

EP - 658

JO - Journal of Asian Natural Products Research

JF - Journal of Asian Natural Products Research

IS - 7

ER -

A new ionone derivative from the leaves of Picrasma quassioides

Abstract

Keywords

ASJC Scopus subject areas

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