A new coumaronochromone and a new alkanoyl-dihydrofuranoflavone glycoside from Eriosema robustum (Fabaceae)

Maurice Ducret Awouafack; Chin Piow Wong; Pierre Tane; Hiroyuki Morita

doi:10.1016/j.phytol.2018.06.024

A new coumaronochromone and a new alkanoyl-dihydrofuranoflavone glycoside from Eriosema robustum (Fabaceae)

Maurice Ducret Awouafack, Chin Piow Wong, Pierre Tane, Hiroyuki Morita^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A new coumaronochromone, eriocoumaronochromone (1), and a new alkanoyl-dihydrofuranoflavone glycoside, robusflavone C (2), as well as seven known compounds, 6-prenylpinocembrin (3), desmoxyphyllin A (4), prutin (5), genistein (6), vitexin (7), kaempferol (8), and p-hydroxy benzoic acid (9), were obtained after phytochemical re-investigation of the EtOAc-soluble portion from the EtOH extract of the twigs of Eriosema robustum. The structures of the new compounds were elucidated by analyses of their spectroscopic data (1D- and 2D- NMR, and HR-ESIMS) and chemical conversion. 1 and 2 exhibited weak antioxidant activity with IC₅₀ 340.3 ± 0.1 and 524.6 ± 0.1 μM in 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay, and possessed weak antimicrobial activity with MICs > 150 μg/mL against Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Candida albicans, and Saccharomyces cerevisiae.

Original language	English
Pages (from-to)	20-24
Number of pages	5
Journal	Phytochemistry Letters
Volume	27
DOIs	https://doi.org/10.1016/j.phytol.2018.06.024
State	Published - 2018/10

Keywords

Antimicrobial
Antioxidant
Eriocoumaronochromone
Eriosema robustum
Robusflavone C

ASJC Scopus subject areas

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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title = "A new coumaronochromone and a new alkanoyl-dihydrofuranoflavone glycoside from Eriosema robustum (Fabaceae)",

abstract = "A new coumaronochromone, eriocoumaronochromone (1), and a new alkanoyl-dihydrofuranoflavone glycoside, robusflavone C (2), as well as seven known compounds, 6-prenylpinocembrin (3), desmoxyphyllin A (4), prutin (5), genistein (6), vitexin (7), kaempferol (8), and p-hydroxy benzoic acid (9), were obtained after phytochemical re-investigation of the EtOAc-soluble portion from the EtOH extract of the twigs of Eriosema robustum. The structures of the new compounds were elucidated by analyses of their spectroscopic data (1D- and 2D- NMR, and HR-ESIMS) and chemical conversion. 1 and 2 exhibited weak antioxidant activity with IC50 340.3 ± 0.1 and 524.6 ± 0.1 μM in 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay, and possessed weak antimicrobial activity with MICs > 150 μg/mL against Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Candida albicans, and Saccharomyces cerevisiae.",

keywords = "Antimicrobial, Antioxidant, Eriocoumaronochromone, Eriosema robustum, Robusflavone C",

author = "Awouafack, {Maurice Ducret} and Wong, {Chin Piow} and Pierre Tane and Hiroyuki Morita",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = oct,

doi = "10.1016/j.phytol.2018.06.024",

language = "英語",

volume = "27",

pages = "20--24",

journal = "Phytochemistry Letters",

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AU - Awouafack, Maurice Ducret

AU - Wong, Chin Piow

AU - Tane, Pierre

AU - Morita, Hiroyuki

PY - 2018/10

Y1 - 2018/10

N2 - A new coumaronochromone, eriocoumaronochromone (1), and a new alkanoyl-dihydrofuranoflavone glycoside, robusflavone C (2), as well as seven known compounds, 6-prenylpinocembrin (3), desmoxyphyllin A (4), prutin (5), genistein (6), vitexin (7), kaempferol (8), and p-hydroxy benzoic acid (9), were obtained after phytochemical re-investigation of the EtOAc-soluble portion from the EtOH extract of the twigs of Eriosema robustum. The structures of the new compounds were elucidated by analyses of their spectroscopic data (1D- and 2D- NMR, and HR-ESIMS) and chemical conversion. 1 and 2 exhibited weak antioxidant activity with IC50 340.3 ± 0.1 and 524.6 ± 0.1 μM in 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay, and possessed weak antimicrobial activity with MICs > 150 μg/mL against Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Candida albicans, and Saccharomyces cerevisiae.

AB - A new coumaronochromone, eriocoumaronochromone (1), and a new alkanoyl-dihydrofuranoflavone glycoside, robusflavone C (2), as well as seven known compounds, 6-prenylpinocembrin (3), desmoxyphyllin A (4), prutin (5), genistein (6), vitexin (7), kaempferol (8), and p-hydroxy benzoic acid (9), were obtained after phytochemical re-investigation of the EtOAc-soluble portion from the EtOH extract of the twigs of Eriosema robustum. The structures of the new compounds were elucidated by analyses of their spectroscopic data (1D- and 2D- NMR, and HR-ESIMS) and chemical conversion. 1 and 2 exhibited weak antioxidant activity with IC50 340.3 ± 0.1 and 524.6 ± 0.1 μM in 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay, and possessed weak antimicrobial activity with MICs > 150 μg/mL against Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Candida albicans, and Saccharomyces cerevisiae.

KW - Antimicrobial

KW - Antioxidant

KW - Eriocoumaronochromone

KW - Eriosema robustum

KW - Robusflavone C

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DO - 10.1016/j.phytol.2018.06.024

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SN - 1874-3900

VL - 27

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JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

A new coumaronochromone and a new alkanoyl-dihydrofuranoflavone glycoside from Eriosema robustum (Fabaceae)

Abstract

Keywords

ASJC Scopus subject areas

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